Exercise improves depression through positive modulation of Brain-Derived Neurotrophic Factor (BDNF). A review based on 100 manuscripts over 20 years

Monèm Jemni; Rashid Zaman; Frederick Carrick; Neil Clarke; Michel Marina; Lindsay Bottoms; Jagdeep Mathharoo; Roger Ramsbottom; Yaodong Gu; Ferman Konukman

doi:10.3389/fphys.2023.1102526

Exercise improves depression through positive modulation of Brain-Derived Neurotrophic Factor (BDNF). A review based on 100 manuscripts over 20 years

Monèm Jemni, Rashid Zaman, Frederick Carrick, Neil Clarke, Michel Marina, Lindsay Bottoms, Jagdeep Mathharoo, Roger Ramsbottom, Yaodong Gu, Ferman Konukman

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Abstract

The aim of this review was to explore the relevant neurobiology and the association between peripheral levels of brain-derived neurotrophic factor (BDNF) and acute and short to long-term exercise regimes, as well as its relation to depression and antidepressant treatment. A 20-years literature search was conducted. The screening process resulted in 100 manuscripts.
Antidepressants as well as acute exercise, particularly high-intensity, elevates BDNF in healthy humans and clinical populations, as evidenced from aerobic and resistance-based studies. Although exercise is increasingly recognised in the management of depression, acute and short-term exercise studies have failed to establish a relationship between the severity of depression and changes in peripheral BDNF. The latter rapidly returns to baseline, possibly indicating a quick re-uptake by the brain, aiding its neuroplasticity functions. The timescale of administration needed for the antidepressants to stimulate biochemical changes is longer than similar increases with acute exercise.

Original language	English
Article number	1102526
Pages (from-to)	1-20
Number of pages	20
Journal	Frontiers in Plant Science
Volume	14
Early online date	8 Mar 2023
DOIs	https://doi.org/10.3389/fphys.2023.1102526
Publication status	Published - 8 Mar 2023

Keywords

BDNF expression
depression treatment
exercise mode
neuroplasticity
physical activity intervention

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10.3389/fphys.2023.1102526Licence: CC BY

Final_Version
© 2023 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/
Final published version, 1.31 MBLicence: CC BY

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Jemni, M., Zaman, R., Carrick, F., Clarke, N., Marina, M., Bottoms, L., Mathharoo, J., Ramsbottom, R., Gu, Y., & Konukman, F. (2023). Exercise improves depression through positive modulation of Brain-Derived Neurotrophic Factor (BDNF). A review based on 100 manuscripts over 20 years. Frontiers in Plant Science, 14, 1-20. Article 1102526. https://doi.org/10.3389/fphys.2023.1102526

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Jemni, M, Zaman, R, Carrick, F, Clarke, N, Marina, M, Bottoms, L, Mathharoo, J, Ramsbottom, R, Gu, Y & Konukman, F 2023, 'Exercise improves depression through positive modulation of Brain-Derived Neurotrophic Factor (BDNF). A review based on 100 manuscripts over 20 years', Frontiers in Plant Science, vol. 14, 1102526, pp. 1-20. https://doi.org/10.3389/fphys.2023.1102526

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AU - Bottoms, Lindsay

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AU - Konukman, Ferman

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AB - The aim of this review was to explore the relevant neurobiology and the association between peripheral levels of brain-derived neurotrophic factor (BDNF) and acute and short to long-term exercise regimes, as well as its relation to depression and antidepressant treatment. A 20-years literature search was conducted. The screening process resulted in 100 manuscripts.Antidepressants as well as acute exercise, particularly high-intensity, elevates BDNF in healthy humans and clinical populations, as evidenced from aerobic and resistance-based studies. Although exercise is increasingly recognised in the management of depression, acute and short-term exercise studies have failed to establish a relationship between the severity of depression and changes in peripheral BDNF. The latter rapidly returns to baseline, possibly indicating a quick re-uptake by the brain, aiding its neuroplasticity functions. The timescale of administration needed for the antidepressants to stimulate biochemical changes is longer than similar increases with acute exercise.

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Exercise improves depression through positive modulation of Brain-Derived Neurotrophic Factor (BDNF). A review based on 100 manuscripts over 20 years

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