Expression of the novel hepatitis C virus core+1/ARF protein in the context of JFH1-based replicons

Ioly Kotta-Loizou, Ioannis Karakasiliotis, Niki Vassilaki, Panagiotis Sakellariou, Ralf Bartenschlager, Penelope Mavromara

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatitis C virus contains a second open reading frame within the core gene, designated core+1/ARF. Here we demonstrate for the first time expression of core+1/ARF protein in the context of a bicistronic JFH1-based replicon and report the production of two isoforms, core+1/L (long) and core+1/S (short), with different kinetics.

Original languageEnglish
Pages (from-to)5164-70
Number of pages7
JournalJournal of Virology
Volume89
Issue number9
DOIs
Publication statusPublished - May 2015

Keywords

  • Cell Line
  • Gene Expression
  • Gene Expression Profiling
  • Hepacivirus/genetics
  • Hepatocytes/virology
  • Humans
  • Protein Isoforms/biosynthesis
  • Replicon
  • Viral Core Proteins/biosynthesis

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