Abstract
Hepatitis C virus contains a second open reading frame within the core gene, designated core+1/ARF. Here we demonstrate for the first time expression of core+1/ARF protein in the context of a bicistronic JFH1-based replicon and report the production of two isoforms, core+1/L (long) and core+1/S (short), with different kinetics.
Original language | English |
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Pages (from-to) | 5164-70 |
Number of pages | 7 |
Journal | Journal of Virology |
Volume | 89 |
Issue number | 9 |
DOIs | |
Publication status | Published - May 2015 |
Keywords
- Cell Line
- Gene Expression
- Gene Expression Profiling
- Hepacivirus/genetics
- Hepatocytes/virology
- Humans
- Protein Isoforms/biosynthesis
- Replicon
- Viral Core Proteins/biosynthesis