TY - JOUR
T1 - Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults
T2 - the Food4Me study
AU - Livingstone, Katherine M.
AU - Celis-Morales, Carlos
AU - Navas-Carretero, Santiago
AU - San-Cristobal, Rodrigo
AU - Forster, Hannah
AU - O'Donovan, Clare B.
AU - Woolhead, Clara
AU - Marsaux, Cyril F. M.
AU - Macready, Anna L.
AU - Fallaize, Rosalind
AU - Kolossa, Silvia
AU - Tsirigoti, Lydia
AU - Lambrinou, Christina P.
AU - Moschonis, George
AU - Godlewska, Magdalena
AU - Surwiłło, Agnieszka
AU - Drevon, Christian A.
AU - Manios, Yannis
AU - Traczyk, Iwona
AU - Gibney, Eileen R.
AU - Brennan, Lorraine
AU - Walsh, Marianne C.
AU - Lovegrove, Julie A.
AU - Martinez, J. Alfredo
AU - Saris, Wim H. M.
AU - Daniel, Hannelore
AU - Gibney, Mike
AU - Mathers, John C.
PY - 2016/2
Y1 - 2016/2
N2 - The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AA v. TT: +1·4 cm; P=0·003) and BMI (+0·9 kg/m2; P=0·001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 1·4 kg/m2 greater BMI (P trend=0·028) and 3·1 cm greater WC (P trend=0·045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.
AB - The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AA v. TT: +1·4 cm; P=0·003) and BMI (+0·9 kg/m2; P=0·001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 1·4 kg/m2 greater BMI (P trend=0·028) and 3·1 cm greater WC (P trend=0·045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.
U2 - 10.1017/S0007114515004675
DO - 10.1017/S0007114515004675
M3 - Article
C2 - 26620191
SN - 0007-1145
VL - 115
SP - 440
EP - 448
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 3
ER -