TY - JOUR
T1 - Formation and measurement of process induced disorder during the manufacture of inhalation medicines
AU - Royall, P.G.
AU - Woodhead, B.
AU - Tang, S.J.
AU - Martin, G.P.
AU - Stockton, B.M.
AU - Murnane, D.
N1 - Copyright Apstj [Full text of this article is not available in the UHRA]
PY - 2011/7/1
Y1 - 2011/7/1
N2 - The development and manufacture of inhalation medicines presents a number of complex challenges to the pharmaceutical scientist. Of paramount importance is delivering the drug particles with an optimal size for deposition in the desired regions of the lung. To achieve this, milling is typically applied to reduce the size of the drug particles destined for inhalation. Comminution has a number of important consequences for the physical properties of the processed drug particles. The generation of process induced disorder (PID) is a major issue which can lead to agglomeration of the powder and failure of the material to meet its specification. This review considers the challenges of achieving pulmonary delivery, the impact that particle size reduction during manufacture has on the properties of the inhaled drug particles and methods that may be employed to determine the extent of PID.
AB - The development and manufacture of inhalation medicines presents a number of complex challenges to the pharmaceutical scientist. Of paramount importance is delivering the drug particles with an optimal size for deposition in the desired regions of the lung. To achieve this, milling is typically applied to reduce the size of the drug particles destined for inhalation. Comminution has a number of important consequences for the physical properties of the processed drug particles. The generation of process induced disorder (PID) is a major issue which can lead to agglomeration of the powder and failure of the material to meet its specification. This review considers the challenges of achieving pulmonary delivery, the impact that particle size reduction during manufacture has on the properties of the inhaled drug particles and methods that may be employed to determine the extent of PID.
KW - calorimetry
KW - dynamic mechanical analysis
KW - dynamic vapour sorption
KW - fourier transform-Raman spectroscopy
KW - micronisation
KW - near infrared spectroscopy
KW - solid-state NMR
KW - X-ray powder diffraction
UR - http://www.scopus.com/inward/record.url?scp=80053111204&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:80053111204
SN - 1773-2247
VL - 21
SP - 311
EP - 318
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
IS - 4
ER -