Gamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1,4 butanediol (1,4-BD; BDO): a literature review with a focus on UK fatalities related to non-medical use

John Corkery, Barbara Loi, Hugh Claridge, Christine Goodair, Ornella Corazza, Simon Elliott, Fabrizio Schifano

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)
2675 Downloads (Pure)

Abstract

Misuse of gamma hydroxybutrate (GHB) and gamma butyrolactone (GBL) has increased greatly since the early 1990s, being implicated in a rising number of deaths. This paper reviews knowledge on GHB and derivatives, and explores the largest series of deaths associated with their non-medical use. Descriptive
analyses of cases associated with GHB/GBL and 1,4 butanediol (1,4-BD) use extracted from the UK’s National Programme on Substance Abuse Deaths database. From 1995 to September 2013, 159 GHB/GBL-associated fatalities were reported. Typical victims: White (92%), young (mean age 32 years); male (82%); with a drug misuse history (70%). Most deaths (79%) were accidental or related to drug use, the remainder (potential) suicides. GHB/GBL alone was implicated in 37%; alcohol 14%; other drugs 28%; other drugs and alcohol 15%. Its endogenous nature and rapid elimination limit toxicological detection. Post-mortem blood levels: mean 482 (range 0 - 6500; S.D. 758) mg/L. Results suggest significant caution is needed when ingesting GHB/GBL, particularly with alcohol, benzodiazepines, opiates, stimulants, and ketamine. More awareness is needed about risks associated with consumption.
Original languageEnglish
Pages (from-to)52-78
JournalNeuroscience and Biobehavioral Reviews
Volume53
Early online date3 Apr 2015
DOIs
Publication statusPublished - Jun 2015

Keywords

  • GHB
  • GBL
  • FATALITIES
  • DEATHS
  • TOXICITY
  • United Kingdom

Fingerprint

Dive into the research topics of 'Gamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1,4 butanediol (1,4-BD; BDO): a literature review with a focus on UK fatalities related to non-medical use'. Together they form a unique fingerprint.

Cite this