Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis

Nader Salari, Amir Hossein Kanjoori, Amin Hosseinian-Far, Razie Hasheminezhad, Kamran Mansouri, Masoud Mohammadi

Research output: Contribution to journalArticlepeer-review

12 Downloads (Pure)


BACKGROUND: Tuberculosis is a bacterial infectious disease, which affects different parts of a human body, mainly lungs and can lead to the patient's death. The aim of this study is to investigate the global prevalence of drug-resistant tuberculosis using a systematic review and meta-analysis.METHODS: In this study, the PubMed, Scopus, Web of Science, Embase, ScienceDirect and Google Scholar repositories were systematically searched to find studies reporting the global prevalence of drug-resistant tuberculosis. The search did not entail a lower time limit, and articles published up until August 2022 were considered. Random effects model was used to perform the analysis. The heterogeneity of the studies was examined with the I 2 test. Data analysis was conducted within the Comprehensive Meta-Analysis software. RESULTS: In the review of 148 studies with a sample size of 318,430 people, the I 2 index showed high heterogeneity (I 2  = 99.6), and accordingly random effects method was used to analyze the results. Publication bias was also examined using the Begg and Mazumdar correlation test which indicated the existence of publication bias in the studies (P = 0.008). According to our meta-analysis, the global pooled prevalence of multi-drug resistant TB is 11.6% (95% CI: 9.1-14.5%). CONCLUSIONS: The global prevalence of drug-resistant tuberculosis was found to be very high, thus health authorities should consider ways to control and manage the disease to prevent a wider spread of tuberculosis and potentially subsequent deaths.
Original languageEnglish
Article number57
Pages (from-to)1-12
Number of pages12
JournalInfectious Diseases of Poverty
Issue number1
Publication statusPublished - 25 May 2023


  • Burden
  • Drug-resistant Tuberculosis
  • Humans
  • Prevalence
  • Tb
  • Tuberculosis
  • Tuberculosis, Multidrug-Resistant
  • outbreak


Dive into the research topics of 'Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this