Abstract
Studies reporting on the cognitive abilities of men and women with Alzheimer's disease (AD) are surprisingly rare. We carried out a meta-analysis of neurocognitive data from 15 studies (n = 828 men; 1,238 women), which revealed a consistent male advantage on verbal and visuospatial tasks and tests of episodic and semantic memory. Moderator regression analyses showed that age, education level, and dementia severity did not significantly predict the male advantage. Reasons posited for this advantage include a reduction of estrogen in postmenopausal women, sex differences in AD pathology, and greater cognitive reserve in men.
| Original language | English |
|---|---|
| Pages (from-to) | 989-998 |
| Number of pages | 10 |
| Journal | Journal of Clinical and Experimental Neuropsychology |
| Volume | 34 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1 Nov 2012 |
Keywords
- APOLIPOPROTEIN-E
- OLDER-ADULTS
- AGE
- GENDER-DIFFERENCES
- Alzheimer's disease
- VASCULAR DEMENTIA
- VERBAL MEMORY
- SEX-DIFFERENCES
- SURGICALLY MENOPAUSAL WOMEN
- Sex differences
- Cognition
- Visuospatial abilities
- ESTROGEN REPLACEMENT
- Verbal abilities
- REPLACEMENT THERAPY