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The haemodialysis population continues to increase and is becoming more elderly and dependent. Despite major advances in technology, long-term clinical outcomes are disappointing, even in low-risk patients. Current definitions of dialysis adequacy, based on urea clearance, need to be broadened to encompass parameters such as β 2 -microglobulin clearance, salt and water balance, and phosphate control. More frequent treatments may be necessary to adequately control uraemia and can improve survival. Haemodiafiltration provides improved β 2 -microglobulin clearance over haemodialysis, and may improve survival. Failures in access provision, particularly over-dependence on tunnelled lines, contribute significantly to morbidity and excess mortality.

Original languageEnglish
Pages (from-to)429-433
Number of pages5
Issue number7
Publication statusPublished - Jul 2011


  • adequacy
  • convection
  • diffusion
  • dry weight
  • haemodiafiltration
  • haemodialysis
  • HEMO study
  • uraemia


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