Murugan Sivalingam, Ken Farrington

Research output: Contribution to journalReview article

5 Citations (Scopus)


The haemodialysis population continues to increase rapidly and is becoming more elderly and dependent. Despite major advances in technology, long-term clinical outcomes are disappointing, even in low-risk patients. Current definitions of dialysis adequacy, based on urea clearance, need to be broadened to encompass parameters such as β2-microglobulin clearance, salt and water balance, and phosphate control. More frequent treatments may be necessary to adequately control uraemia and to improve survival. Haemodiafiltration provides improved β2-microglobulin clearance over haemodialysis, and may improve outcomes. Failures in access provision, particularly over-dependence on tunnelled lines, contribute significantly to morbidity and excess mortality.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
Issue number8
Publication statusPublished - 1 Aug 2007


  • β-microglobulin
  • adequacy
  • convection
  • diffusion
  • dry weight
  • haemodiafiltration
  • haemodialysis
  • HEMO study
  • uraemia


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