Abstract

This mini-review examines the strategy of combining viral protein sequence conservation with drug-binding potential to identify novel antiviral targets, focusing on internal proteins of influenza A and other RNA viruses. The importance of combating viral genetic variability and reducing the likelihood of resistance development is emphasised in the context of sequence redundancy in viral datasets. It covers recent structural and functional updates, as well as drug targeting efforts for three internal influenza A viral proteins: Basic Polymerase 2, Nuclear Export Protein, and Nucleoprotein. The review discusses new insights into protein interactions, potential inhibitors, and recent drug discovery efforts. Similar approaches beyond influenza including Hepatitis E, SARS-CoV-2, Dengue, and the HIV-1 virus are also covered briefly.
Original languageEnglish
Article number110414
Pages (from-to)1-7
Number of pages7
JournalVirology
Volume604
Early online date17 Jan 2025
DOIs
Publication statusE-pub ahead of print - 17 Jan 2025

Keywords

  • Conservation
  • binding site
  • sequence redundancy
  • Virtual screening
  • computational drug discovery

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