Headspace Oxygen Concentration Measurement for Pharmaceutical Glass Bottles in Open-path Optical Environment Using TDLAS/WMS

Qiwu Luo, Cao Song, Chunhua Yang, Weihua Gui, Yichuang Sun, Zoe Jeffrey

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
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Accurate measurement of oxygen concentration for pharmaceutical glass bottles is of great significance to ensure the asepsis of medicine and stability of ingredients. With merits of high sensitivity, low cost, non-contact, and real time response, the wavelength-modulation-based tunable diode laser absorption spectroscopy (TDLAS/WMS) technology shows great potential to achieve in-site oxygen concentration detection by the single-line spectrum measurement. This paper focuses on headspace oxygen concentration measurement in open-path optical environment, which is extremely challenging owing to the short light path length and random ambient noises. First, a signal reconstruction method is established based on discrete-time wavelet packet transform (DWPT), where random noise suppression is implicitly achieved. Then, oxygen concentration is inversed among the data between two adjacent valley values of the demodulated 2nd harmonic signal by multiple linear regression (MLR), and the linear discriminant analysis (LDA) is imported to enhance the information sparsity of 2nd harmonic signal matrix and to address the multi-collinearity problem. Simulation results prove our proposed method achieved considerable detection accuracy with average absolute error of 0.05%. This paper also designed a TDLAS/WMS prototype, the experimental results aiming at glass bottles with different oxygen concentration of 0%, 5%, 10% and 21% in open path optical environment indicate our method has achieved an encouraging average absolute error of 0.54%, and can survive well when the normalized SNR is within 0.85 to 1. These results promise that the proposed methodology can be widely applied in in-site AOI instrumentation of headspace oxygen concentration measurement for glass vials.
Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalIEEE Transactions on Instrumentation and Measurement
Issue number8
Early online date10 Dec 2019
Publication statusE-pub ahead of print - 10 Dec 2019
EventIEEE I2MTC 2021 - The International Instrumentation and Measurement Technology Conference - Ottawa, Canada
Duration: 17 May 202120 May 2021


  • AOI, TDLAS, WMS, oxygen concentration


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