TY - JOUR
T1 - High Content Image Analysis of Cellular Responses of the Murine J774A.1 Cell Line and Primary Human Cells Alveolar Macrophages to an Extended Panel of Pharmaceutical Agents
AU - Tietze, Lysann
AU - Urbano, Laura
AU - Eisenmann, Stephan
AU - Schwarzinger, Jacqueline
AU - Kollan, Julia
AU - Forbes, Ben
AU - Dailey, Lea Ann
AU - Hädrich, Gabriela
N1 - © 2025, The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/
PY - 2025/1/7
Y1 - 2025/1/7
N2 - In vitro screening of macrophages for drug-induced effects, such as phospholipidosis, is useful for detecting potentially problematic compounds in the preclinical development of oral inhaled products. High-content image analysis (HCIA) is a multi-parameter approach for cytotoxicity screening. This study provides new insights into HCIA-derived response patterns of murine J774A.1 cells and primary human alveolar macrophages (hAM).
AB - In vitro screening of macrophages for drug-induced effects, such as phospholipidosis, is useful for detecting potentially problematic compounds in the preclinical development of oral inhaled products. High-content image analysis (HCIA) is a multi-parameter approach for cytotoxicity screening. This study provides new insights into HCIA-derived response patterns of murine J774A.1 cells and primary human alveolar macrophages (hAM).
U2 - 10.1007/s11095-024-03806-y
DO - 10.1007/s11095-024-03806-y
M3 - Article
SN - 1573-904X
JO - Pharmaceutical Research
JF - Pharmaceutical Research
ER -