How hosts control worms

M.J. Stear; K. Bairden; J.L. Duncan; P.H. Holmes; Quintin McKellar; M. Park; S. Strain; M. Murray; S.C. Bishop; G. Gettinby

doi:10.1038/37895

How hosts control worms

M.J. Stear, K. Bairden, J.L. Duncan, P.H. Holmes, Quintin McKellar, M. Park, S. Strain, M. Murray, S.C. Bishop, G. Gettinby

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Abstract

Nematodes are a major cause of disease and death in humans, domestic animals and wildlife. Understanding why some individuals suffer severely whereas others exposed to the same infection remain healthy may assist in the development of rational and sustainable strategies to control infection. Here, using a quantitative genetic analysis of the parasitic nematode population that had accumulated naturally in lambs, we find no apparent influence of host genetics on nematode numbers but an extremely strong influence on average worm length and fecundity. Our results indicate that in growing lambs the main manifestation of genetic resistance is the control of worm fecundity

Original language	English
Pages (from-to)	27
Number of pages	1
Journal	Nature
Volume	389
Issue number	6646
DOIs	https://doi.org/10.1038/37895
Publication status	Published - 4 Sept 1997

Keywords

OSTERTAGIA-CIRCUMCINCTA
COMPONENTS

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title = "How hosts control worms",

abstract = "Nematodes are a major cause of disease and death in humans, domestic animals and wildlife. Understanding why some individuals suffer severely whereas others exposed to the same infection remain healthy may assist in the development of rational and sustainable strategies to control infection. Here, using a quantitative genetic analysis of the parasitic nematode population that had accumulated naturally in lambs, we find no apparent influence of host genetics on nematode numbers but an extremely strong influence on average worm length and fecundity. Our results indicate that in growing lambs the main manifestation of genetic resistance is the control of worm fecundity",

keywords = "OSTERTAGIA-CIRCUMCINCTA, COMPONENTS",

author = "M.J. Stear and K. Bairden and J.L. Duncan and P.H. Holmes and Quintin McKellar and M. Park and S. Strain and M. Murray and S.C. Bishop and G. Gettinby",

year = "1997",

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T1 - How hosts control worms

AU - Stear, M.J.

AU - Bairden, K.

AU - Duncan, J.L.

AU - Holmes, P.H.

AU - McKellar, Quintin

AU - Park, M.

AU - Strain, S.

AU - Murray, M.

AU - Bishop, S.C.

AU - Gettinby, G.

PY - 1997/9/4

Y1 - 1997/9/4

N2 - Nematodes are a major cause of disease and death in humans, domestic animals and wildlife. Understanding why some individuals suffer severely whereas others exposed to the same infection remain healthy may assist in the development of rational and sustainable strategies to control infection. Here, using a quantitative genetic analysis of the parasitic nematode population that had accumulated naturally in lambs, we find no apparent influence of host genetics on nematode numbers but an extremely strong influence on average worm length and fecundity. Our results indicate that in growing lambs the main manifestation of genetic resistance is the control of worm fecundity

AB - Nematodes are a major cause of disease and death in humans, domestic animals and wildlife. Understanding why some individuals suffer severely whereas others exposed to the same infection remain healthy may assist in the development of rational and sustainable strategies to control infection. Here, using a quantitative genetic analysis of the parasitic nematode population that had accumulated naturally in lambs, we find no apparent influence of host genetics on nematode numbers but an extremely strong influence on average worm length and fecundity. Our results indicate that in growing lambs the main manifestation of genetic resistance is the control of worm fecundity

KW - OSTERTAGIA-CIRCUMCINCTA

KW - COMPONENTS

U2 - 10.1038/37895

DO - 10.1038/37895

M3 - Comment/debate

VL - 389

SP - 27

JO - Nature

JF - Nature

IS - 6646

ER -

How hosts control worms

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Keywords

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