Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery

Marc Brown; Stuart A. Jones; Weijiang He; Gary P. Martin

Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery

Marc Brown, Stuart A. Jones, Weijiang He, Gary P. Martin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

Abstract

Hyaluronan (HA) is a polyanionic, polysaccharide ubiquitous in mammals where it has a protective, structure stabilising and shock-absorbing role. The unique viscoelastic nature of HA along with its biocompatibility and non-immunogenicity has led to its use in a number of clinical applications. The ability of HA to localise therapeutic agents in the superficial layers of the skin has led to the commericalisation of Solaraze((R)), a 3% diclofenac in 2.5% HA gel, for the topical treatment of actinic keratoses (AKs), the third most common skin complaint in the US. However, the means by which HA enhances topical drug delivery remains unclear. The data described in this study demonstrate that HA offers promotes the delivery and localisation of drugs in the skin. In addition, it would appear that the molecular weight and concentration of HA may be critical for such drug delivery properties. (c) 2006 American Chemical Society

Original language	English
Title of host publication	Polysaccharides for Drug Delivery and Pharmaceutical Applications
Editors	R.H. Marchessault, F. Ravenelle, X.X. Zhu
Place of Publication	Washington
Publisher	American Chemical Society (ACS)
Pages	141-153
Number of pages	13
ISBN (Print)	0-8412-3960-6
Publication status	Published - 2006
Event	Symposium on Polysaccharides for Drug Delivery and Pharmaceutical Applications held at the 228th ACS National Meeting - Philadelphia Duration: 22 Aug 2004 → 26 Aug 2004

Conference

Conference	Symposium on Polysaccharides for Drug Delivery and Pharmaceutical Applications held at the 228th ACS National Meeting
City	Philadelphia
Period	22/08/04 → 26/08/04

Keywords

AQUEOUS-SOLUTION
ACID GEL
SKIN

Cite this

@inproceedings{73acbc64879c40f2a7ab9ff0e0957227,

title = "Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery",

abstract = "Hyaluronan (HA) is a polyanionic, polysaccharide ubiquitous in mammals where it has a protective, structure stabilising and shock-absorbing role. The unique viscoelastic nature of HA along with its biocompatibility and non-immunogenicity has led to its use in a number of clinical applications. The ability of HA to localise therapeutic agents in the superficial layers of the skin has led to the commericalisation of Solaraze((R)), a 3% diclofenac in 2.5% HA gel, for the topical treatment of actinic keratoses (AKs), the third most common skin complaint in the US. However, the means by which HA enhances topical drug delivery remains unclear. The data described in this study demonstrate that HA offers promotes the delivery and localisation of drugs in the skin. In addition, it would appear that the molecular weight and concentration of HA may be critical for such drug delivery properties. (c) 2006 American Chemical Society",

keywords = "AQUEOUS-SOLUTION, ACID GEL, SKIN",

author = "Marc Brown and Jones, {Stuart A.} and Weijiang He and Martin, {Gary P.}",

year = "2006",

language = "English",

isbn = "0-8412-3960-6",

pages = "141--153",

editor = "R.H. Marchessault and F. Ravenelle and X.X. Zhu",

booktitle = "Polysaccharides for Drug Delivery and Pharmaceutical Applications",

publisher = "American Chemical Society (ACS)",

address = "United States",

note = "Symposium on Polysaccharides for Drug Delivery and Pharmaceutical Applications held at the 228th ACS National Meeting ; Conference date: 22-08-2004 Through 26-08-2004",

}

Brown, M, Jones, SA, He, W & Martin, GP 2006, Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery. in RH Marchessault, F Ravenelle & XX Zhu (eds), Polysaccharides for Drug Delivery and Pharmaceutical Applications. American Chemical Society (ACS), Washington, pp. 141-153, Symposium on Polysaccharides for Drug Delivery and Pharmaceutical Applications held at the 228th ACS National Meeting, Philadelphia, 22/08/04.

Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery. / Brown, Marc; Jones, Stuart A.; He, Weijiang et al.
Polysaccharides for Drug Delivery and Pharmaceutical Applications. ed. / R.H. Marchessault; F. Ravenelle; X.X. Zhu. Washington: American Chemical Society (ACS), 2006. p. 141-153.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery

AU - Brown, Marc

AU - Jones, Stuart A.

AU - He, Weijiang

AU - Martin, Gary P.

PY - 2006

Y1 - 2006

N2 - Hyaluronan (HA) is a polyanionic, polysaccharide ubiquitous in mammals where it has a protective, structure stabilising and shock-absorbing role. The unique viscoelastic nature of HA along with its biocompatibility and non-immunogenicity has led to its use in a number of clinical applications. The ability of HA to localise therapeutic agents in the superficial layers of the skin has led to the commericalisation of Solaraze((R)), a 3% diclofenac in 2.5% HA gel, for the topical treatment of actinic keratoses (AKs), the third most common skin complaint in the US. However, the means by which HA enhances topical drug delivery remains unclear. The data described in this study demonstrate that HA offers promotes the delivery and localisation of drugs in the skin. In addition, it would appear that the molecular weight and concentration of HA may be critical for such drug delivery properties. (c) 2006 American Chemical Society

AB - Hyaluronan (HA) is a polyanionic, polysaccharide ubiquitous in mammals where it has a protective, structure stabilising and shock-absorbing role. The unique viscoelastic nature of HA along with its biocompatibility and non-immunogenicity has led to its use in a number of clinical applications. The ability of HA to localise therapeutic agents in the superficial layers of the skin has led to the commericalisation of Solaraze((R)), a 3% diclofenac in 2.5% HA gel, for the topical treatment of actinic keratoses (AKs), the third most common skin complaint in the US. However, the means by which HA enhances topical drug delivery remains unclear. The data described in this study demonstrate that HA offers promotes the delivery and localisation of drugs in the skin. In addition, it would appear that the molecular weight and concentration of HA may be critical for such drug delivery properties. (c) 2006 American Chemical Society

KW - AQUEOUS-SOLUTION

KW - ACID GEL

KW - SKIN

M3 - Conference contribution

SN - 0-8412-3960-6

SP - 141

EP - 153

BT - Polysaccharides for Drug Delivery and Pharmaceutical Applications

A2 - Marchessault, R.H.

A2 - Ravenelle, F.

A2 - Zhu, X.X.

PB - American Chemical Society (ACS)

CY - Washington

T2 - Symposium on Polysaccharides for Drug Delivery and Pharmaceutical Applications held at the 228th ACS National Meeting

Y2 - 22 August 2004 through 26 August 2004

ER -

Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery

Abstract

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Keywords

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