Identification and Validation of Mode of Action of Chalcones as Anti-Tubercular Compounds

Keyphrases

• Antitubercular Agents 100%
• Mode of Action 100%
• Chalcone 100%
• Minimum Inhibitory Concentration 75%
• Mycolic Acid 50%
• Fatty Acid Methyl Esters 50%
• Biological Activity 50%
• Selectivity Index 50%
• Mycolic Acid Biosynthesis 50%
• Methyl Ester 50%
• InhA 50%
• Fatty Acid Synthase 50%
• Synthetic Compounds 25%
• New Drugs 25%
• Broth Microdilution 25%
• Sodium Hydroxide 25%
• Post-antibiotic Era 25%
• M. Bovis BCG 25%
• Tuberculosis 25%
• Emerging Problems 25%
• Claisen 25%
• Cytotoxic Studies 25%
• Global Health Issue 25%
• Anti-tuberculosis 25%
• Aromatic Aldehydes 25%
• Overexpressing 25%
• Acetophenone 25%
• Analgesic 25%
• Spectral Analysis 25%
• Cellular Targets 25%
• Mycobacterial Lipids 25%
• CLSI Guidelines 25%
• Tuberculosis Drugs 25%
• Condensation 25%
• Natural Compounds 25%
• Infrared Spectroscopy 25%
• Mouse Macrophages 25%
• Drug-resistant Mycobacterium Tuberculosis 25%
• Synthesized Compounds 25%
• Extensively Drug-resistant Tuberculosis 25%
• Multidrug-resistant Tuberculosis (MDR-TB) 25%
• Infectious Diseases 25%
• J774 Macrophages 25%
• 13C NMR Spectroscopy 25%
• 1H nuclear Magnetic Resonance (1H NMR) 25%
• Tuberculosis Regimen 25%
• Antituberculosis Chemotherapy 25%
• Resistant Tuberculosis 25%
• Heterocyclic Compounds 25%
• Mycobacterium Tuberculosis (M. tb) 25%
• Mass Spectrometry 25%
• Antimicrobial Resistance 25%
• Ethanol 25%
• Line Compound 25%
• Toxic Drugs 25%
• Tuberculosis Bacilli 25%
• Tuberculosis multidrug-resistant 25%
• Dose Effect 25%
• J774A.1 25%
• Organic Synthesis 25%
• Antioxidant 25%
• Recrystallized 25%
• Poor Compliance 25%
• Medicinal Chemistry 25%
• Mycobacterium Tuberculosis Strains 25%

Chemistry

• Antitubercular 100%
• Chalcone 100%
• Mycolic Acid 100%
• Minimum Inhibitory Concentration 75%
• Methyl Ester 50%
• Bioactivity 50%
• Fatty Acids 50%
• Fatty Acid Methyl Ester 50%
• Antimalarial 25%
• 13C NMR Spectroscopy 25%
• Antimalarial Agent 25%
• Toxic 25%
• Mass Spectrometry 25%
• Sodium Hydroxide 25%
• 1H NMR Spectroscopy 25%
• Heterocyclic Compound 25%
• Condensation 25%
• Melting Point 25%
• Aldehyde 25%
• Chemistry 25%
• Antioxidant Agent 25%
• Acetophenone 25%
• Nonsteroid Antiinflammatory Agent 25%
• Dilution 25%
• Spectroscopy 25%
• Tuberculostatic Agent 25%
• Antibiotic Resistance 25%
• new drug 25%
• Thin Layer Chromatography 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Chalcone Derivative 100%
• Mycolic Acid 100%
• Minimum Inhibitory Concentration 75%
• Fatty Acid Ester 50%
• Biological Activity 50%
• Fatty Acid Synthase 50%
• Mycobacterium Tuberculosis 50%
• Anti-Inflammatory Drug 25%
• Antimicrobial Resistance 25%
• Acetophenone Derivative 25%
• Antibiotic Resistance 25%
• Infrared Spectroscopy 25%
• Sodium Hydroxide 25%
• Mycobacterium Bovis BCG 25%
• Tuberculostatic Agent 25%
• Infection 25%
• Pharmaceutical Chemistry 25%
• Heterocyclic Compound 25%
• Extensively Drug-Resistant Tuberculosis 25%
• Multi-Drug-Resistant Tuberculosis 25%
• Antimalarial Agent 25%
• Carbon 13 25%
• Disease 25%
• Analgesic Agent 25%
• Antiinfective Agent 25%
• Aldehyde 25%
• Drug Resistant Tuberculosis 25%
• Antioxidant 25%