Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma

C.E.C.A. Hop, Y. Wang, S. Kumar, M.V.S. Elipe, C.E. Raab, D.C. Dean, G.K. Poon, C.-A. Keohane, J. Strauss, S.-H.L. Chiu, N. Curtis, J. Elliott, U. Gerhard, K. Locker, D. Morrison, R. Mortishire-Smith, A.P. Watt, D.C. Evans

Research output: Contribution to conferencePaperpeer-review

Abstract

The metabolism of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma was described. The samples were prepared for analysis by protein precipitation followed by centrifugation. It was shown that the radiochromatograms were remarkably different from that obtained with rat hepatocytes. The mass spectrometric data in the negative ion mode was obtained without TFA acid in the mobile phase. The keto acid structure was proposed based on the mass spectrometric and chromatographic data.
Original languageEnglish
Pages87-88
Number of pages2
Publication statusPublished - 1 Jan 2002
EventProceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, United States
Duration: 2 Jun 20026 Jun 2002

Conference

ConferenceProceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/TerritoryUnited States
CityOrlando
Period2/06/026/06/02

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