Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma

C.E.C.A. Hop; Y. Wang; S. Kumar; M.V.S. Elipe; C.E. Raab; D.C. Dean; G.K. Poon; C.-A. Keohane; J. Strauss; S.-H.L. Chiu; N. Curtis; J. Elliott; U. Gerhard; K. Locker; D. Morrison; R. Mortishire-Smith; A.P. Watt; D.C. Evans

Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma

C.E.C.A. Hop, Y. Wang, S. Kumar, M.V.S. Elipe, C.E. Raab, D.C. Dean, G.K. Poon, C.-A. Keohane, J. Strauss, S.-H.L. Chiu, N. Curtis, J. Elliott, U. Gerhard, K. Locker, D. Morrison, R. Mortishire-Smith, A.P. Watt, D.C. Evans

Research output: Contribution to conference › Paper › peer-review

Abstract

The metabolism of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma was described. The samples were prepared for analysis by protein precipitation followed by centrifugation. It was shown that the radiochromatograms were remarkably different from that obtained with rat hepatocytes. The mass spectrometric data in the negative ion mode was obtained without TFA acid in the mobile phase. The keto acid structure was proposed based on the mass spectrometric and chromatographic data.

Original language	English
Pages	87-88
Number of pages	2
Publication status	Published - 1 Jan 2002
Event	Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, United States Duration: 2 Jun 2002 → 6 Jun 2002

Conference

Conference	Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/Territory	United States
City	Orlando
Period	2/06/02 → 6/06/02

Cite this

Hop, C. E. C. A., Wang, Y., Kumar, S., Elipe, M. V. S., Raab, C. E., Dean, D. C., Poon, G. K., Keohane, C-A., Strauss, J., Chiu, S-HL., Curtis, N., Elliott, J., Gerhard, U., Locker, K., Morrison, D., Mortishire-Smith, R., Watt, A. P., & Evans, D. C. (2002). Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma. 87-88. Paper presented at Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, United States.

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abstract = "The metabolism of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma was described. The samples were prepared for analysis by protein precipitation followed by centrifugation. It was shown that the radiochromatograms were remarkably different from that obtained with rat hepatocytes. The mass spectrometric data in the negative ion mode was obtained without TFA acid in the mobile phase. The keto acid structure was proposed based on the mass spectrometric and chromatographic data.",

author = "C.E.C.A. Hop and Y. Wang and S. Kumar and M.V.S. Elipe and C.E. Raab and D.C. Dean and G.K. Poon and C.-A. Keohane and J. Strauss and S.-H.L. Chiu and N. Curtis and J. Elliott and U. Gerhard and K. Locker and D. Morrison and R. Mortishire-Smith and A.P. Watt and D.C. Evans",

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Hop, CECA, Wang, Y, Kumar, S, Elipe, MVS, Raab, CE, Dean, DC, Poon, GK, Keohane, C-A, Strauss, J, Chiu, S-HL, Curtis, N, Elliott, J, Gerhard, U, Locker, K, Morrison, D, Mortishire-Smith, R, Watt, AP & Evans, DC 2002, 'Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma', Paper presented at Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, United States, 2/06/02 - 6/06/02 pp. 87-88.

TY - CONF

T1 - Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma

AU - Hop, C.E.C.A.

AU - Wang, Y.

AU - Kumar, S.

AU - Elipe, M.V.S.

AU - Raab, C.E.

AU - Dean, D.C.

AU - Poon, G.K.

AU - Keohane, C.-A.

AU - Strauss, J.

AU - Chiu, S.-H.L.

AU - Curtis, N.

AU - Elliott, J.

AU - Gerhard, U.

AU - Locker, K.

AU - Morrison, D.

AU - Mortishire-Smith, R.

AU - Watt, A.P.

AU - Evans, D.C.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - The metabolism of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma was described. The samples were prepared for analysis by protein precipitation followed by centrifugation. It was shown that the radiochromatograms were remarkably different from that obtained with rat hepatocytes. The mass spectrometric data in the negative ion mode was obtained without TFA acid in the mobile phase. The keto acid structure was proposed based on the mass spectrometric and chromatographic data.

AB - The metabolism of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma was described. The samples were prepared for analysis by protein precipitation followed by centrifugation. It was shown that the radiochromatograms were remarkably different from that obtained with rat hepatocytes. The mass spectrometric data in the negative ion mode was obtained without TFA acid in the mobile phase. The keto acid structure was proposed based on the mass spectrometric and chromatographic data.

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M3 - Paper

AN - SCOPUS:2442688006

SP - 87

EP - 88

T2 - Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics

Y2 - 2 June 2002 through 6 June 2002

ER -

Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma

Abstract

Conference

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