Abstract
The metabolism of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma was described. The samples were prepared for analysis by protein precipitation followed by centrifugation. It was shown that the radiochromatograms were remarkably different from that obtained with rat hepatocytes. The mass spectrometric data in the negative ion mode was obtained without TFA acid in the mobile phase. The keto acid structure was proposed based on the mass spectrometric and chromatographic data.
Original language | English |
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Pages | 87-88 |
Number of pages | 2 |
Publication status | Published - 1 Jan 2002 |
Event | Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, United States Duration: 2 Jun 2002 → 6 Jun 2002 |
Conference
Conference | Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics |
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Country/Territory | United States |
City | Orlando |
Period | 2/06/02 → 6/06/02 |