In Vitro Cell Models for Ophthalmic Drug Development Applications

Sara Shafaie, Victoria Hutter, Michael T. Cook, Marc Brown, David Y.S. Chau

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)
308 Downloads (Pure)

Abstract

Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the development
of in vitro representations of organs for drug toxicity assessment. Due to the ever-increasing interest in ocular drug delivery as a route for administration as well as the rise of new ophthalmic therapeutics, there is a demand for physiologically accurate in vitro models of the eye to assess drug delivery and safety of new ocular
medicines. This review summarizes current existing ocular models and highlights the important factors and limitations that need to be considered during their use.
Original languageEnglish
Pages (from-to)94-108
JournalBioResearch Open Access
Volume5
Issue number1
DOIs
Publication statusPublished - 20 Apr 2016

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