In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents

L. Xu; J. Zhao; T. Zhang; Z. Yang; Guogang Ren

doi:10.1002/tox.20418

In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents

L. Xu, J. Zhao, T. Zhang, Z. Yang, Guogang Ren

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Abstract

The effects of nano particles of CuO on voltage-dependent potassium currents were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus using the whole-cell patch-clamp techniques. Nano particles of CuO had small effects on transient outward potassium current (IA, no statistical significance) and mainly inhibited delayed rectifier potassium current (IK) in the concentration of 5 × 10-5 g/mL. Nano particles of CuO didn't shift the steady-state activation curve of IK and IA but negatively shifted the inactivation curve of IK. The effects on inactivation curve of IA had no statistical significance. These results suggested that blockades of K+ currents by nano particles of CuO could be preferential for Ik for the first time. This may interfere with the normal function of nerve cells.

Original language	English
Pages (from-to)	211-217
Journal	Environmental Toxicology
Volume	24
Issue number	3
DOIs	https://doi.org/10.1002/tox.20418
Publication status	Published - 2008

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title = "In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents",

abstract = "The effects of nano particles of CuO on voltage-dependent potassium currents were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus using the whole-cell patch-clamp techniques. Nano particles of CuO had small effects on transient outward potassium current (IA, no statistical significance) and mainly inhibited delayed rectifier potassium current (IK) in the concentration of 5 × 10-5 g/mL. Nano particles of CuO didn't shift the steady-state activation curve of IK and IA but negatively shifted the inactivation curve of IK. The effects on inactivation curve of IA had no statistical significance. These results suggested that blockades of K+ currents by nano particles of CuO could be preferential for Ik for the first time. This may interfere with the normal function of nerve cells.",

author = "L. Xu and J. Zhao and T. Zhang and Z. Yang and Guogang Ren",

note = "The original article can be found at: http://www3.interscience.wiley.com Copyright Wiley. DOI: 10.1002/tox.20418 [Full text of this article is not available in the UHRA]",

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TY - JOUR

T1 - In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents

AU - Xu, L.

AU - Zhao, J.

AU - Zhang, T.

AU - Yang, Z.

AU - Ren, Guogang

N1 - The original article can be found at: http://www3.interscience.wiley.com Copyright Wiley. DOI: 10.1002/tox.20418 [Full text of this article is not available in the UHRA]

PY - 2008

Y1 - 2008

N2 - The effects of nano particles of CuO on voltage-dependent potassium currents were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus using the whole-cell patch-clamp techniques. Nano particles of CuO had small effects on transient outward potassium current (IA, no statistical significance) and mainly inhibited delayed rectifier potassium current (IK) in the concentration of 5 × 10-5 g/mL. Nano particles of CuO didn't shift the steady-state activation curve of IK and IA but negatively shifted the inactivation curve of IK. The effects on inactivation curve of IA had no statistical significance. These results suggested that blockades of K+ currents by nano particles of CuO could be preferential for Ik for the first time. This may interfere with the normal function of nerve cells.

AB - The effects of nano particles of CuO on voltage-dependent potassium currents were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus using the whole-cell patch-clamp techniques. Nano particles of CuO had small effects on transient outward potassium current (IA, no statistical significance) and mainly inhibited delayed rectifier potassium current (IK) in the concentration of 5 × 10-5 g/mL. Nano particles of CuO didn't shift the steady-state activation curve of IK and IA but negatively shifted the inactivation curve of IK. The effects on inactivation curve of IA had no statistical significance. These results suggested that blockades of K+ currents by nano particles of CuO could be preferential for Ik for the first time. This may interfere with the normal function of nerve cells.

U2 - 10.1002/tox.20418

DO - 10.1002/tox.20418

M3 - Article

SN - 1520-4081

VL - 24

SP - 211

EP - 217

JO - Environmental Toxicology

JF - Environmental Toxicology

IS - 3

ER -

In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents

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