Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments

M.J. Traynor, Marc Brown, A. Pannala, P. Beck, G. P. Martin

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)
132 Downloads (Pure)

Abstract

Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram (R) ER tablets and T-long (R) capsules was significantly increased in the presence of ethanol. Conversely, a decrease in the rate of tramadol release was seen from Tridural (TM) extended-release tablets in the presence of alcohol.

Original languageEnglish
Pages (from-to)885-889
Number of pages5
JournalDrug Development and Industrial Pharmacy
Volume34
Issue number8
DOIs
Publication statusPublished - 2008

Keywords

  • tramadol
  • controlled release
  • alcohol
  • in vitro
  • POSTOPERATIVE PAIN
  • MATRICES

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