Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells

A. R. Baydoun; D. M. L. Morgan

doi:10.1038/sj.bjp.0702231

Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells

A. R. Baydoun
, D. M. L. Morgan

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

111 Downloads (Pure)

Abstract

We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by α-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages.

Original language	English
Pages (from-to)	1511-1516
Journal	British Journal of Pharmacology
Volume	125
Issue number	7
DOIs	https://doi.org/10.1038/sj.bjp.0702231
Publication status	Published - 1998

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title = "Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells",

abstract = "We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by α-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages.",

author = "Baydoun, \{A. R.\} and Morgan, \{D. M. L.\}",

note = "Original article can be found at: --http://www.nature.com/bjp/index.html--Copyright British Pharmacological Society and Nature Publishing Group DOI : 10.1038/sj.bjp.0702231",

year = "1998",

doi = "10.1038/sj.bjp.0702231",

language = "English",

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journal = "British Journal of Pharmacology",

issn = "0007-1188",

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T1 - Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells

AU - Baydoun, A. R.

AU - Morgan, D. M. L.

N1 - Original article can be found at: --http://www.nature.com/bjp/index.html--Copyright British Pharmacological Society and Nature Publishing Group DOI : 10.1038/sj.bjp.0702231

PY - 1998

Y1 - 1998

N2 - We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by α-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages.

AB - We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by α-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages.

U2 - 10.1038/sj.bjp.0702231

DO - 10.1038/sj.bjp.0702231

M3 - Article

SN - 0007-1188

VL - 125

SP - 1511

EP - 1516

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 7

ER -

Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells

Abstract

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