TY - JOUR
T1 - Innovations in Chewable Formulations
T2 - The Novelty and Applications of 3D Printing in Drug Product Design
AU - Rodríguez-Pombo, Lucía
AU - Awad, Atheer
AU - Basit, Abdul W.
AU - Alvarez-Lorenzo, Carmen
AU - Goyanes, Alvaro
N1 - Funding Information:
The research was partially supported by MCIN (PID 2020-113881RB-I00/AEI/10.13039/501100011033), Spain, Xunta de Galicia (ED431C 2020/17), and FEDER.
Funding Information:
L.R.P. acknowledges the predoctoral fellowship provided by the Ministerio de Universidades (Formación de Profesorado Universitario (FPU 2020)). The graphical abstract was created using BioRender.com (accessed on 27 July 2022). E’s rights are owned by a third party.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/8
Y1 - 2022/8
N2 - Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric and dysphagia patients. Their benefits stretch beyond human use to also include veterinary applications, improving administration and palatability in different animal species. Despite their advantages, current chewable formulations do not account for individualised dosing and palatability preferences. In light of this, three-dimensional (3D) printing, and in particular the semi-solid extrusion technology, has been suggested as a novel manufacturing method for producing customised chewable dosage forms. This advanced approach offers flexibility for selecting patient-specific doses, excipients, and organoleptic properties, which are critical for ensuring efficacy, safety and adherence to the treatment. This review provides an overview of the latest advancements in chewable dosage forms for human and veterinary use, highlighting the motivations behind their use and covering formulation considerations, as well as regulatory aspects.
AB - Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric and dysphagia patients. Their benefits stretch beyond human use to also include veterinary applications, improving administration and palatability in different animal species. Despite their advantages, current chewable formulations do not account for individualised dosing and palatability preferences. In light of this, three-dimensional (3D) printing, and in particular the semi-solid extrusion technology, has been suggested as a novel manufacturing method for producing customised chewable dosage forms. This advanced approach offers flexibility for selecting patient-specific doses, excipients, and organoleptic properties, which are critical for ensuring efficacy, safety and adherence to the treatment. This review provides an overview of the latest advancements in chewable dosage forms for human and veterinary use, highlighting the motivations behind their use and covering formulation considerations, as well as regulatory aspects.
KW - 3D printed medicines and pharmaceuticals
KW - chewable oral formulations
KW - digital healthcare
KW - human and veterinary medicine
KW - orally disintegrating formulations
KW - orodispersible tablets and films
KW - patient acceptability and palatability
KW - precision medicine
KW - taste masking
UR - http://www.scopus.com/inward/record.url?scp=85137384313&partnerID=8YFLogxK
U2 - 10.3390/pharmaceutics14081732
DO - 10.3390/pharmaceutics14081732
M3 - Review article
AN - SCOPUS:85137384313
SN - 1999-4923
VL - 14
JO - Pharmaceutics
JF - Pharmaceutics
IS - 8
M1 - 1732
ER -