Abstract
Since the discovery of the anti-influenza drugs Oseltamivir and Zanamivir using computer aided drug design methods, there have been significant applications of molecular modelling methodologies applied to influenza A virus drug discovery, such as molecular dynamics simulation, molecular docking and virtual screening. This review provides a brief general introduction to molecular modelling in the context of drug discovery and then focuses on the advances and impact of integrating these methods with specific reference to potential influenza A antiviral drug targets.
Original language | English |
---|---|
Journal | Drug Discovery Today |
Early online date | 19 Nov 2020 |
DOIs | |
Publication status | E-pub ahead of print - 19 Nov 2020 |