Interactions of inhaled drugs with active transport mechanisms in bronchial epithelial cell layers in vitro

Victoria Hutter; Constanze Hilgendorf; Vanessa Zann; Anne Cooper; David Pritchard; Cynthia Bosquillon

Interactions of inhaled drugs with active transport mechanisms in bronchial epithelial cell layers in vitro

Victoria Hutter, Constanze Hilgendorf, Vanessa Zann, Anne Cooper, David Pritchard, Cynthia Bosquillon

Research output: Contribution to conference › Abstract › peer-review

Abstract

The transport of 3H-digoxin (an established MDR1 and OATP substrate) was assessed alone, and in the presence of marketed inhaled drug compounds in Calu-3 cell monolayers cultured at an air-liquid interface for 21 days. Net secretory transport of 3H-digoxin was significantly reduced (p<0.01) in the presence of both budesonide and formoterol but not in the presence of salbutamol. Results suggest that therapeutically relevant concentrations of marketed inhaled drugs might interact with drug transporters in the bronchial epithelium

Original language	English
Publication status	Published - 2012
Event	UK PharmSci 2012 - Nottingham, United Kingdom Duration: 12 Sept 2012 → 14 Sept 2012

Conference

Conference	UK PharmSci 2012
Country/Territory	United Kingdom
City	Nottingham
Period	12/09/12 → 14/09/12

Cite this

@conference{da4f885558d34a3f835fb7a983063032,

title = "Interactions of inhaled drugs with active transport mechanisms in bronchial epithelial cell layers in vitro",

abstract = "The transport of 3H-digoxin (an established MDR1 and OATP substrate) was assessed alone, and in the presence of marketed inhaled drug compounds in Calu-3 cell monolayers cultured at an air-liquid interface for 21 days. Net secretory transport of 3H-digoxin was significantly reduced (p<0.01) in the presence of both budesonide and formoterol but not in the presence of salbutamol. Results suggest that therapeutically relevant concentrations of marketed inhaled drugs might interact with drug transporters in the bronchial epithelium",

author = "Victoria Hutter and Constanze Hilgendorf and Vanessa Zann and Anne Cooper and David Pritchard and Cynthia Bosquillon",

year = "2012",

language = "English",

note = "UK PharmSci 2012 ; Conference date: 12-09-2012 Through 14-09-2012",

}

TY - CONF

T1 - Interactions of inhaled drugs with active transport mechanisms in bronchial epithelial cell layers in vitro

AU - Hutter, Victoria

AU - Hilgendorf, Constanze

AU - Zann, Vanessa

AU - Cooper, Anne

AU - Pritchard, David

AU - Bosquillon, Cynthia

PY - 2012

Y1 - 2012

N2 - The transport of 3H-digoxin (an established MDR1 and OATP substrate) was assessed alone, and in the presence of marketed inhaled drug compounds in Calu-3 cell monolayers cultured at an air-liquid interface for 21 days. Net secretory transport of 3H-digoxin was significantly reduced (p<0.01) in the presence of both budesonide and formoterol but not in the presence of salbutamol. Results suggest that therapeutically relevant concentrations of marketed inhaled drugs might interact with drug transporters in the bronchial epithelium

AB - The transport of 3H-digoxin (an established MDR1 and OATP substrate) was assessed alone, and in the presence of marketed inhaled drug compounds in Calu-3 cell monolayers cultured at an air-liquid interface for 21 days. Net secretory transport of 3H-digoxin was significantly reduced (p<0.01) in the presence of both budesonide and formoterol but not in the presence of salbutamol. Results suggest that therapeutically relevant concentrations of marketed inhaled drugs might interact with drug transporters in the bronchial epithelium

M3 - Abstract

T2 - UK PharmSci 2012

Y2 - 12 September 2012 through 14 September 2012

ER -

Interactions of inhaled drugs with active transport mechanisms in bronchial epithelial cell layers in vitro

Abstract

Conference

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