Investigation of the mode of action of nematode neuropeptides

Christopher Keating; Lindy Holden-Dye; Robert J. Walker

doi:10.1002/(SICI)1096-9063(199603)46:3<263::AID-PS346>3.0.CO;2-U

Investigation of the mode of action of nematode neuropeptides

Christopher Keating, Lindy Holden-Dye, Robert J. Walker

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The neuropeptide AF2 has a complex set of actions on the dorsal muscle strip of Ascaris suum, including a potentiation of the acetylcholine-stimulated muscle contraction. Caffeine at 100 μm and 5 mm inhibited this potentiation, as did 100 μm theophylline in two out of six studies. The cyclic-AMP-potentiating compounds IBMX, dibutyryl cAMP and forskolin had no effect on the AF2-induced potentiation of the acetylcholine-stimulated muscle contraction. These preliminary data suggest that the potentiating action of AF2 is not mediated by a cAMP pathway

Original language	English
Pages (from-to)	263-266
Journal	Pesticide Science
Volume	46
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1096-9063(199603)46:3<263::AID-PS346>3.0.CO;2-U
Publication status	Published - Mar 1996

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10.1002/(SICI)1096-9063(199603)46:3<263::AID-PS346>3.0.CO;2-U

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title = "Investigation of the mode of action of nematode neuropeptides",

abstract = "The neuropeptide AF2 has a complex set of actions on the dorsal muscle strip of Ascaris suum, including a potentiation of the acetylcholine-stimulated muscle contraction. Caffeine at 100 μm and 5 mm inhibited this potentiation, as did 100 μm theophylline in two out of six studies. The cyclic-AMP-potentiating compounds IBMX, dibutyryl cAMP and forskolin had no effect on the AF2-induced potentiation of the acetylcholine-stimulated muscle contraction. These preliminary data suggest that the potentiating action of AF2 is not mediated by a cAMP pathway",

author = "Christopher Keating and Lindy Holden-Dye and Walker, {Robert J.}",

year = "1996",

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doi = "10.1002/(SICI)1096-9063(199603)46:3<263::AID-PS346>3.0.CO;2-U",

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T1 - Investigation of the mode of action of nematode neuropeptides

AU - Keating, Christopher

AU - Holden-Dye, Lindy

AU - Walker, Robert J.

PY - 1996/3

Y1 - 1996/3

N2 - The neuropeptide AF2 has a complex set of actions on the dorsal muscle strip of Ascaris suum, including a potentiation of the acetylcholine-stimulated muscle contraction. Caffeine at 100 μm and 5 mm inhibited this potentiation, as did 100 μm theophylline in two out of six studies. The cyclic-AMP-potentiating compounds IBMX, dibutyryl cAMP and forskolin had no effect on the AF2-induced potentiation of the acetylcholine-stimulated muscle contraction. These preliminary data suggest that the potentiating action of AF2 is not mediated by a cAMP pathway

AB - The neuropeptide AF2 has a complex set of actions on the dorsal muscle strip of Ascaris suum, including a potentiation of the acetylcholine-stimulated muscle contraction. Caffeine at 100 μm and 5 mm inhibited this potentiation, as did 100 μm theophylline in two out of six studies. The cyclic-AMP-potentiating compounds IBMX, dibutyryl cAMP and forskolin had no effect on the AF2-induced potentiation of the acetylcholine-stimulated muscle contraction. These preliminary data suggest that the potentiating action of AF2 is not mediated by a cAMP pathway

U2 - 10.1002/(SICI)1096-9063(199603)46:3<263::AID-PS346>3.0.CO;2-U

DO - 10.1002/(SICI)1096-9063(199603)46:3<263::AID-PS346>3.0.CO;2-U

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VL - 46

SP - 263

EP - 266

JO - Pesticide Science

JF - Pesticide Science

IS - 3

ER -

Investigation of the mode of action of nematode neuropeptides

Abstract

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