Lattice design and 3D-printing of PEEK with Ca10(OH)(PO4)3 and in-vitro bio-composite for bone implant

B. I. Oladapo, S. O. Ismail, B. Oluwole, F. T. Omigbodun, M. A. Olawumi, M. A. Muhammad

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
23 Downloads (Pure)

Abstract

The addition of biomaterials such as Calcium hydroxyapatite (cHAp) and incorporation of porosity into poly-ether-ether-ketone (PEEK) are effective ways to improve bone-implant interfaces and osseointegration of PEEK composite. Hence, the morphological effects of nanocomposite on surfaces biocompatibility of a newly fabricated composite of PEEK polymer and cHAp for a bone implant, using additive manufacturing (AM) were investigated. Fused deposition modeling (FDM) method and a surface treatment strategy were employed to create a microporous scaffold. PEEK osteointegration was slow and, therefore, it was accelerated by surface coatings with the incorporation of bioactive cHAp, with enhanced mechanical and biological behaviors for bone implants. Characterization of the new PEEK/cHAp composite was done by X-ray diffraction (XRD), differential scanning calorimetry (DSC), mechanical tests of traction and flexion, thermal dynamic mechanical analysis (DMA). Also, the PEEK/cHAp induced the formation of apatite after immersion in the simulated body fluid of DMEM for different days to check its biological bioactivity for an implant. In-vivo results depicted that the osseointegration and the biological activity around the PEEK/cHAp composite were higher than that of PEEK. The increase in the mechanical performance of cHAp-coated PEEK can be attributed to the increase in the degree of crystallinity and accumulation of residual polymer.
Original languageEnglish
Pages (from-to)50-62
Number of pages13
JournalInternational Journal of Biological Macromolecules
Volume165
Early online date23 Sept 2020
DOIs
Publication statusPublished - 15 Dec 2020

Keywords

  • Biocompatible
  • Bone implant
  • Nanostructure
  • PEEK/cHAp

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