This study aimed to identify the relationships between lifelong learning, quality of life, and self-efficacy of older adults. One thousand and three participants of a lifelong educational program participated; the mean age was 50.6 (SD = 7.8, range: 18–78). Findings revealed that the patterns of study established a positive association with quality of life, but a negative correlation with their psychosomatic complaints. It also found that the more respondents enrolled in courses, the more somatic complaints they suffered. Multiple regression analysis models indicate that the determinants of good quality of life in older adult learners aged 60 and over were good self-efficacy and the continuation of study after graduation.