Ligands which bind weakly to vancomycin: Studies by 13C NMR spectroscopy

C.M. Pearce, D.H. Williams, Ute Gerhard

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


C NMR chemical shifts of vancomycin have been used to obtain the association constants for a number of ligands which bind weakly to the antibiotic. The change in these C chemical shifts upon stepwise addition of ligands provides evidence that the ligands bind in a manner analogous to natural cell-wall precursor analogues. The binding constants obtained are in good agreement with those determined earlier by other methods. Where the ligands are amino acids (glycine or alanine), a potential alkylammonium to amide carbonyl interaction does not promote binding.
Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalJournal of the Chemical Society, Perkin Transactions 2
Issue number1
Publication statusPublished - 1 Jan 1995


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