Mass spectrometric investigation of synthetic glycoside of muramyl dipeptide immobilized on fumed silica surface

N-Acetylmuramyl-l-alanyl-d-isoglutamine or muramyl dipeptide is a cleavage product of peptidoglycan by lysozyme. This study explored the use of the temperature-programmed desorption mass spectrometry (TPDMS) in analysis of glycoside of muramyl dipeptide: O-{(4-tert-butylcyclohexyl)-2-acetamido-2,3-dideoxy-β-d-glucopyranoside-3-yl}-d-lactoyl-l-alanyl-d-isoglutamine (MDP) on the surface of fumed silica. Stages of pyrolysis of MDP in condensed state and on the silica surface have been determined. Three stages have been clear identified under pyrolysis of MDP on the silica surface. Kinetic parameters of thermal reactions on the fumed silica surface and in the condensed state have been calculated.