Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signalling

Annemie Deiteren, Joris de Man, Christopher Keating, Wen Jiang, Heiko de Schepper, Paul Pelckmans, Sven Francque, Benedicte de Winter

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
60 Downloads (Pure)

Abstract

Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral hypersensitivity in vivo in an acute and postinflammatory rat model of colitis.
Original languageEnglish
Pages (from-to)1709-1720
JournalNeurogastroenterology and Motility
Volume27
Issue number12
Early online date4 Sept 2015
DOIs
Publication statusPublished - 19 Nov 2015

Keywords

  • afferent nerve signalling
  • colitis
  • mechanosensitivity
  • splanchnic nerves
  • TNBS
  • visceral hypersensitivity

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