Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signalling

Annemie Deiteren; Joris  de Man; Christopher Keating; Wen Jiang; Heiko de Schepper; Paul Pelckmans; Sven Francque; Benedicte de Winter

doi:10.1111/nmo.12667

Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signalling

Annemie Deiteren
, Joris de Man
, Christopher Keating
, Wen Jiang
, Heiko de Schepper
, Paul Pelckmans
, Sven Francque
, Benedicte de Winter

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

70 Downloads (Pure)

Abstract

Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral hypersensitivity in vivo in an acute and postinflammatory rat model of colitis.

Original language	English
Pages (from-to)	1709-1720
Journal	Neurogastroenterology and Motility
Volume	27
Issue number	12
Early online date	4 Sept 2015
DOIs	https://doi.org/10.1111/nmo.12667
Publication status	Published - 19 Nov 2015

Keywords

afferent nerve signalling
colitis
mechanosensitivity
splanchnic nerves
TNBS
visceral hypersensitivity

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10.1111/nmo.12667

annemie colitis paper 2015 resubmit
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 1.26 MBLicence: CC BY-NC

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title = "Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signalling",

abstract = "Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral hypersensitivity in vivo in an acute and postinflammatory rat model of colitis.",

keywords = "afferent nerve signalling, colitis, mechanosensitivity, splanchnic nerves, TNBS, visceral hypersensitivity",

author = "Annemie Deiteren and \{de Man\}, Joris and Christopher Keating and Wen Jiang and \{de Schepper\}, Heiko and Paul Pelckmans and Sven Francque and \{de Winter\}, Benedicte",

note = "This is the peer reviewed version of the following article: Deiteren, A., De Man, J. G., Keating, C., Jiang, W., De Schepper, H. U., Pelckmans, P. A., Francque, S. M. and De Winter, B. Y. (2015), Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signaling. Neurogastroenterology \& Motility, 27: 1709–1720, which has been published in final form at doi:10.1111/nmo.12667. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.",

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month = nov,

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doi = "10.1111/nmo.12667",

language = "English",

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T2 - focus on splanchnic afferent nerve signalling

AU - Deiteren, Annemie

AU - de Man, Joris

AU - Keating, Christopher

AU - Jiang, Wen

AU - de Schepper, Heiko

AU - Pelckmans, Paul

AU - Francque, Sven

AU - de Winter, Benedicte

N1 - This is the peer reviewed version of the following article: Deiteren, A., De Man, J. G., Keating, C., Jiang, W., De Schepper, H. U., Pelckmans, P. A., Francque, S. M. and De Winter, B. Y. (2015), Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signaling. Neurogastroenterology & Motility, 27: 1709–1720, which has been published in final form at doi:10.1111/nmo.12667. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

PY - 2015/11/19

Y1 - 2015/11/19

N2 - Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral hypersensitivity in vivo in an acute and postinflammatory rat model of colitis.

AB - Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral hypersensitivity in vivo in an acute and postinflammatory rat model of colitis.

KW - afferent nerve signalling

KW - colitis

KW - mechanosensitivity

KW - splanchnic nerves

KW - TNBS

KW - visceral hypersensitivity

U2 - 10.1111/nmo.12667

DO - 10.1111/nmo.12667

M3 - Article

SN - 1350-1925

VL - 27

SP - 1709

EP - 1720

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

IS - 12

ER -

Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signalling

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