Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study

Rodrigo San-Cristobal; Santiago Navas-Carretero; Katherine M Livingstone; Carlos Celis-Morales; Anna L Macready; Rosalind Fallaize; Clare B O'Donovan; Christina P Lambrinou; George Moschonis; Cyril F M Marsaux; Yannis Manios; Miroslaw Jarosz; Hannelore Daniel; Eileen R Gibney; Lorraine Brennan; Christian A Drevon; Thomas E Gundersen; Mike Gibney; Wim H M Saris; Julie A Lovegrove; Keith Grimaldi; Laurence D Parnell; Jildau Bouwman; Ben Van Ommen; John C Mathers; J Alfredo Martinez

doi:10.3390/nu9101107

Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study

Rodrigo San-Cristobal, Santiago Navas-Carretero, Katherine M Livingstone, Carlos Celis-Morales, Anna L Macready, Rosalind Fallaize, Clare B O'Donovan, Christina P Lambrinou, George Moschonis, Cyril F M Marsaux, Yannis Manios, Miroslaw Jarosz, Hannelore Daniel, Eileen R Gibney, Lorraine Brennan, Christian A Drevon, Thomas E Gundersen, Mike Gibney, Wim H M Saris, Julie A LovegroveKeith Grimaldi, Laurence D Parnell, Jildau Bouwman, Ben Van Ommen, John C Mathers, J Alfredo Martinez

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Abstract

Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated measures analyses showed a significantly greater decrease in total cholesterol in participants with a low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant reduction in total carotenoids, while among those with a low GRS, there was no difference associated with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers.

Original language	English
Article number	1107
Number of pages	17
Journal	Nutrients
Volume	9
Issue number	10
DOIs	https://doi.org/10.3390/nu9101107
Publication status	Published - 11 Oct 2017

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Journal Article

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10.3390/nu9101107Licence: CC BY

San-Cristobal et al. (2017) NutrientsFinal published version, 878 KBLicence: CC BY

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San-Cristobal, R., Navas-Carretero, S., Livingstone, K. M., Celis-Morales, C., Macready, A. L., Fallaize, R., O'Donovan, C. B., Lambrinou, C. P., Moschonis, G., Marsaux, C. F. M., Manios, Y., Jarosz, M., Daniel, H., Gibney, E. R., Brennan, L., Drevon, C. A., Gundersen, T. E., Gibney, M., Saris, W. H. M., ... Martinez, J. A. (2017). Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study. Nutrients, 9(10), Article 1107. https://doi.org/10.3390/nu9101107

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abstract = "Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated measures analyses showed a significantly greater decrease in total cholesterol in participants with a low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant reduction in total carotenoids, while among those with a low GRS, there was no difference associated with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers.",

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author = "Rodrigo San-Cristobal and Santiago Navas-Carretero and Livingstone, {Katherine M} and Carlos Celis-Morales and Macready, {Anna L} and Rosalind Fallaize and O'Donovan, {Clare B} and Lambrinou, {Christina P} and George Moschonis and Marsaux, {Cyril F M} and Yannis Manios and Miroslaw Jarosz and Hannelore Daniel and Gibney, {Eileen R} and Lorraine Brennan and Drevon, {Christian A} and Gundersen, {Thomas E} and Mike Gibney and Saris, {Wim H M} and Lovegrove, {Julie A} and Keith Grimaldi and Parnell, {Laurence D} and Jildau Bouwman and {Van Ommen}, Ben and Mathers, {John C} and Martinez, {J Alfredo}",

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San-Cristobal, R, Navas-Carretero, S, Livingstone, KM, Celis-Morales, C, Macready, AL, Fallaize, R, O'Donovan, CB, Lambrinou, CP, Moschonis, G, Marsaux, CFM, Manios, Y, Jarosz, M, Daniel, H, Gibney, ER, Brennan, L, Drevon, CA, Gundersen, TE, Gibney, M, Saris, WHM, Lovegrove, JA, Grimaldi, K, Parnell, LD, Bouwman, J, Van Ommen, B, Mathers, JC & Martinez, JA 2017, 'Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study', Nutrients, vol. 9, no. 10, 1107. https://doi.org/10.3390/nu9101107

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AU - San-Cristobal, Rodrigo

AU - Navas-Carretero, Santiago

AU - Livingstone, Katherine M

AU - Celis-Morales, Carlos

AU - Macready, Anna L

AU - Fallaize, Rosalind

AU - O'Donovan, Clare B

AU - Lambrinou, Christina P

AU - Moschonis, George

AU - Marsaux, Cyril F M

AU - Manios, Yannis

AU - Jarosz, Miroslaw

AU - Daniel, Hannelore

AU - Gibney, Eileen R

AU - Brennan, Lorraine

AU - Drevon, Christian A

AU - Gundersen, Thomas E

AU - Gibney, Mike

AU - Saris, Wim H M

AU - Lovegrove, Julie A

AU - Grimaldi, Keith

AU - Parnell, Laurence D

AU - Bouwman, Jildau

AU - Van Ommen, Ben

AU - Mathers, John C

AU - Martinez, J Alfredo

PY - 2017/10/11

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N2 - Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated measures analyses showed a significantly greater decrease in total cholesterol in participants with a low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant reduction in total carotenoids, while among those with a low GRS, there was no difference associated with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers.

AB - Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated measures analyses showed a significantly greater decrease in total cholesterol in participants with a low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant reduction in total carotenoids, while among those with a low GRS, there was no difference associated with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers.

KW - Journal Article

U2 - 10.3390/nu9101107

DO - 10.3390/nu9101107

M3 - Article

C2 - 29019927

SN - 2072-6643

VL - 9

JO - Nutrients

JF - Nutrients

IS - 10

M1 - 1107

ER -

Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study

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