Mental Fatigue in Individuals with Psychiatric Disorders: A Scoping Review

Kristina Mozuraityte, Agne Stanyte, Naomi Fineberg, Alessandro Serretti, Julija Gecaite-Stonceine, Julius Burkauskas

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Objective: The aim of this study was to complete a scoping review of the published literature describing the relationship between mental fatigue and various psychiatric disorders, in order to better understand its frequency and clinical impact, and to provide recommendations for future clinical research.
Methods: A scoping review using PubMed/MEDLINE, Cochrane and PsychArticles databases was conducted using the keywords “mental fatigue”, “mental tiredness” or “mental exhaustion”, and completed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols Extension for Scoping Reviews 2018 checklist.
Results: We extracted 10 studies fulfilling our inclusion criteria from a total of publications. Mental fatigue was studied within mood disorders, anxiety disorders, obsessive compulsive disorder, and obsessive-compulsive personality disorder. A commonly used tool to measure mental fatigue in these samples was the Multidimensional Fatigue Inventory-20. Specific cognitive factors (unhelpful beliefs about sleep, symptom-focused rumination) and personality risk factors (harm avoidance, self directedness, cooperativeness, persistence) were relevant to predicting mental fatigue symptoms and rates of mental fatigue may vary with gender and diagnosis.
Conclusion: Research into mental fatigue in adult psychiatric sample was limited to a few psychiatric disorders and requires further investigation.
Original languageEnglish
Number of pages11
JournalInternational Journal of Psychiatry in Clinical Practice
Early online date10 Oct 2022
Publication statusE-pub ahead of print - 10 Oct 2022


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