Metabolism of captopril carboxyl ester derivatives for percutaneous absorption

D.R. Gullick; M.J. Ingram; W.J. Pugh; P.A. Cox; P. Gard; J.D. Smart; G.P. Moss

doi:10.1211/jpp/61.02.0004

Metabolism of captopril carboxyl ester derivatives for percutaneous absorption

D.R. Gullick, M.J. Ingram, W.J. Pugh, P.A. Cox, P. Gard, J.D. Smart, G.P. Moss

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

To determine the metabolism of captopril n-carboxyl derivatives and how this may impact on their use as transdermal prodrugs. The pharmacological activity of the ester derivatives was also characterised in order to compare the angiotensin converting enzyme inhibitory potency of the derivatives compared with the parent drug, captopril.

Original language	English
Pages (from-to)	159-165
Journal	Journal of Pharmacy and Pharmacology
Volume	61
Issue number	2
DOIs	https://doi.org/10.1211/jpp/61.02.0004
Publication status	Published - 2009

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title = "Metabolism of captopril carboxyl ester derivatives for percutaneous absorption",

abstract = "To determine the metabolism of captopril n-carboxyl derivatives and how this may impact on their use as transdermal prodrugs. The pharmacological activity of the ester derivatives was also characterised in order to compare the angiotensin converting enzyme inhibitory potency of the derivatives compared with the parent drug, captopril.",

author = "D.R. Gullick and M.J. Ingram and W.J. Pugh and P.A. Cox and P. Gard and J.D. Smart and G.P. Moss",

note = "Original article can be found at: http://www.medicinescomplete.com/journals/jpp/current/ Copyright Pharmaceutical Press [Full text of this article is not available in the UHRA]",

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language = "English",

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pages = "159--165",

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T1 - Metabolism of captopril carboxyl ester derivatives for percutaneous absorption

AU - Gullick, D.R.

AU - Ingram, M.J.

AU - Pugh, W.J.

AU - Cox, P.A.

AU - Gard, P.

AU - Smart, J.D.

AU - Moss, G.P.

N1 - Original article can be found at: http://www.medicinescomplete.com/journals/jpp/current/ Copyright Pharmaceutical Press [Full text of this article is not available in the UHRA]

PY - 2009

Y1 - 2009

N2 - To determine the metabolism of captopril n-carboxyl derivatives and how this may impact on their use as transdermal prodrugs. The pharmacological activity of the ester derivatives was also characterised in order to compare the angiotensin converting enzyme inhibitory potency of the derivatives compared with the parent drug, captopril.

AB - To determine the metabolism of captopril n-carboxyl derivatives and how this may impact on their use as transdermal prodrugs. The pharmacological activity of the ester derivatives was also characterised in order to compare the angiotensin converting enzyme inhibitory potency of the derivatives compared with the parent drug, captopril.

U2 - 10.1211/jpp/61.02.0004

DO - 10.1211/jpp/61.02.0004

M3 - Article

SN - 0022-3573

VL - 61

SP - 159

EP - 165

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

IS - 2

ER -

Metabolism of captopril carboxyl ester derivatives for percutaneous absorption

Abstract

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