Methodologies for Assessing the Acceptability of Oral Formulations among children and older adults: A Systematic Review

Sejal  Ranmal; Fiona  O’Brien; Felipe  Lopez; Fabrice  Ruiz; Mine   Orlu; Catherine  Tuleu; Jennifer  Walsh; Fang Liu

doi:10.1016/j.drudis.2018.01.038

Methodologies for Assessing the Acceptability of Oral Formulations among children and older adults: A Systematic Review

Sejal Ranmal
, Fiona O’Brien
, Felipe Lopez
, Fabrice Ruiz
, Mine Orlu
, Catherine Tuleu
, Jennifer Walsh
, Fang Liu

Research output: Contribution to journal › Review article › peer-review

53 Citations (Scopus)

176 Downloads (Pure)

Abstract

Acceptability of medicinal products in children and older populations is pivotal in ensuring adherence and therapeutic outcomes. This review systematically identifies studies reporting on formulation aspects of oral medications that affect their acceptability in these patient groups. Particular emphasis is placed on the evaluation of the methodologies employed in the studies. Sixty-eight studies were included for analysis, with 51 (75%) in children and 17 (25%) in older populations. The studies evaluated a range of oral formulations; however, the methodologies used differ considerably in participants’ characteristics, study settings, tools, acceptability definitions and criteria. It is evident that there is a lack of standardisation in study design as well as the assessment methods used in assessing acceptability of medicines in children and older populations. This review presents a systematic analysis on methods employed for assessing acceptability of oral medicines in children and older adults, to provide insights and recommendations regarding the design of reliable instruments in future studies.

Original language	English
Pages (from-to)	830-847
Number of pages	18
Journal	Drug Discovery Today
Volume	23
Issue number	4
Early online date	31 Jan 2018
DOIs	https://doi.org/10.1016/j.drudis.2018.01.038
Publication status	Published - 1 Apr 2018

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Ranmal et al oral formulations published versionFinal published version, 902 KBLicence: CC BY-NC-ND

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abstract = "Acceptability of medicinal products in children and older populations is pivotal in ensuring adherence and therapeutic outcomes. This review systematically identifies studies reporting on formulation aspects of oral medications that affect their acceptability in these patient groups. Particular emphasis is placed on the evaluation of the methodologies employed in the studies. Sixty-eight studies were included for analysis, with 51 (75\%) in children and 17 (25\%) in older populations. The studies evaluated a range of oral formulations; however, the methodologies used differ considerably in participants{\textquoteright} characteristics, study settings, tools, acceptability definitions and criteria. It is evident that there is a lack of standardisation in study design as well as the assessment methods used in assessing acceptability of medicines in children and older populations. This review presents a systematic analysis on methods employed for assessing acceptability of oral medicines in children and older adults, to provide insights and recommendations regarding the design of reliable instruments in future studies.",

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AU - Orlu, Mine

AU - Tuleu, Catherine

AU - Walsh, Jennifer

AU - Liu, Fang

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Methodologies for Assessing the Acceptability of Oral Formulations among children and older adults: A Systematic Review

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