Missing steps in a staircase: a qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials

Munya Dimairo, Jonathan Boote, Steven A. Julious, Jon Nicholl, Susan Todd

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)
88 Downloads (Pure)

Abstract

Despite the promising benefits of adaptive designs (ADs), their routine use, especially in confirmatory trials, is lagging behind the prominence given to them in the statistical literature. Much of the previous research to understand barriers and potential facilitators to the use of ADs has been driven from a pharmaceutical drug
development perspective, with little focus on trials in the public sector. In this paper, we explore key stakeholders’ experiences, perceptions and views on barriers and facilitators to the use of ADs in publicly funded confirmatory trials
Original languageEnglish
Article number430
Number of pages16
JournalTrials
Volume16
DOIs
Publication statusPublished - 28 Sept 2015

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