[Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule

Sian H Crook; Brian E Mann; Anthony J H M Meijer; Harry Adams; Philip Sawle; David Scapens; Roberto Motterlini

doi:10.1039/c1dt10125k

[Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule

Sian H Crook, Brian E Mann, Anthony J H M Meijer, Harry Adams, Philip Sawle, David Scapens, Roberto Motterlini

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

[Mn(CO)(4){S(2)CNMe(CH(2)CO(2)H)}], 1, is shown to be a CO releasing molecule providing at least three moles CO per mole of compound. The mechanism of CO loss is dissociative and reversible and was investigated using Gaussian 09 calculations. The reversible binding of CO results in a relatively stable solution of the compound, while in the presence of a CO receptor or a ligand to prevent the rebinding of CO, the CO is lost rapidly. The X-ray structure was determined.

Original language	English
Pages (from-to)	4230-5
Number of pages	6
Journal	Dalton Transactions
Volume	40
Issue number	16
DOIs	https://doi.org/10.1039/c1dt10125k
Publication status	Published - 28 Apr 2011

Keywords

Animals
Carbon Monoxide
Cell Line
Cell Survival
Crystallography, X-Ray
Drug Carriers
Kinetics
Macrophages
Manganese
Mice
Organometallic Compounds
Solubility
Water
Journal Article
Research Support, Non-U.S. Gov't

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10.1039/c1dt10125k

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title = "[Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule",

abstract = "[Mn(CO)(4){S(2)CNMe(CH(2)CO(2)H)}], 1, is shown to be a CO releasing molecule providing at least three moles CO per mole of compound. The mechanism of CO loss is dissociative and reversible and was investigated using Gaussian 09 calculations. The reversible binding of CO results in a relatively stable solution of the compound, while in the presence of a CO receptor or a ligand to prevent the rebinding of CO, the CO is lost rapidly. The X-ray structure was determined.",

keywords = "Animals, Carbon Monoxide, Cell Line, Cell Survival, Crystallography, X-Ray, Drug Carriers, Kinetics, Macrophages, Manganese, Mice, Organometallic Compounds, Solubility, Water, Journal Article, Research Support, Non-U.S. Gov't",

author = "Crook, {Sian H} and Mann, {Brian E} and Meijer, {Anthony J H M} and Harry Adams and Philip Sawle and David Scapens and Roberto Motterlini",

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doi = "10.1039/c1dt10125k",

language = "English",

volume = "40",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - [Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule

AU - Crook, Sian H

AU - Mann, Brian E

AU - Meijer, Anthony J H M

AU - Adams, Harry

AU - Sawle, Philip

AU - Scapens, David

AU - Motterlini, Roberto

PY - 2011/4/28

Y1 - 2011/4/28

N2 - [Mn(CO)(4){S(2)CNMe(CH(2)CO(2)H)}], 1, is shown to be a CO releasing molecule providing at least three moles CO per mole of compound. The mechanism of CO loss is dissociative and reversible and was investigated using Gaussian 09 calculations. The reversible binding of CO results in a relatively stable solution of the compound, while in the presence of a CO receptor or a ligand to prevent the rebinding of CO, the CO is lost rapidly. The X-ray structure was determined.

AB - [Mn(CO)(4){S(2)CNMe(CH(2)CO(2)H)}], 1, is shown to be a CO releasing molecule providing at least three moles CO per mole of compound. The mechanism of CO loss is dissociative and reversible and was investigated using Gaussian 09 calculations. The reversible binding of CO results in a relatively stable solution of the compound, while in the presence of a CO receptor or a ligand to prevent the rebinding of CO, the CO is lost rapidly. The X-ray structure was determined.

KW - Animals

KW - Carbon Monoxide

KW - Cell Line

KW - Cell Survival

KW - Crystallography, X-Ray

KW - Drug Carriers

KW - Kinetics

KW - Macrophages

KW - Manganese

KW - Mice

KW - Organometallic Compounds

KW - Solubility

KW - Water

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1039/c1dt10125k

DO - 10.1039/c1dt10125k

M3 - Article

C2 - 21403944

SN - 1477-9226

VL - 40

SP - 4230

EP - 4235

JO - Dalton Transactions

JF - Dalton Transactions

IS - 16

ER -

[Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule

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Keywords

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