TY - JOUR
T1 - Moisture uptake of polyoxyethylene glycol glycerides used as matrices for drug delivery
T2 - kinetic modelling and practical implications
AU - Qi, Sheng
AU - Belton, Peter
AU - McAuley, William James
AU - Codoni, Dorothy
AU - Darji, Neerav
PY - 2013/4
Y1 - 2013/4
N2 - Gelucire 50/13, a polyoxyethylene glycol glyceride mixture, has been widely used in drug delivery, but its moisture uptake behaviour is still poorly understood. In this study, the effects of relative humidity, temperature, and drug incorporation on the moisture uptake of Gelucire are reported in relation to their practical implications for preparation of solid dispersions using this material
AB - Gelucire 50/13, a polyoxyethylene glycol glyceride mixture, has been widely used in drug delivery, but its moisture uptake behaviour is still poorly understood. In this study, the effects of relative humidity, temperature, and drug incorporation on the moisture uptake of Gelucire are reported in relation to their practical implications for preparation of solid dispersions using this material
U2 - 10.1007/s11095-012-0948-5
DO - 10.1007/s11095-012-0948-5
M3 - Article
SN - 0724-8741
VL - 30
SP - 1123
EP - 1136
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 4
ER -