Moisture uptake of polyoxyethylene glycol glycerides used as matrices for drug delivery: kinetic modelling and practical implications

Sheng  Qi; Peter Belton; William James McAuley; Dorothy Codoni; Neerav Darji

doi:10.1007/s11095-012-0948-5

Moisture uptake of polyoxyethylene glycol glycerides used as matrices for drug delivery: kinetic modelling and practical implications

Sheng Qi
, Peter Belton
, William James McAuley
, Dorothy Codoni
, Neerav Darji

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Gelucire 50/13, a polyoxyethylene glycol glyceride mixture, has been widely used in drug delivery, but its moisture uptake behaviour is still poorly understood. In this study, the effects of relative humidity, temperature, and drug incorporation on the moisture uptake of Gelucire are reported in relation to their practical implications for preparation of solid dispersions using this material

Original language	English
Pages (from-to)	1123-1136
Journal	Pharmaceutical Research
Volume	30
Issue number	4
DOIs	https://doi.org/10.1007/s11095-012-0948-5
Publication status	Published - Apr 2013

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title = "Moisture uptake of polyoxyethylene glycol glycerides used as matrices for drug delivery: kinetic modelling and practical implications",

abstract = "Gelucire 50/13, a polyoxyethylene glycol glyceride mixture, has been widely used in drug delivery, but its moisture uptake behaviour is still poorly understood. In this study, the effects of relative humidity, temperature, and drug incorporation on the moisture uptake of Gelucire are reported in relation to their practical implications for preparation of solid dispersions using this material",

author = "Sheng Qi and Peter Belton and McAuley, \{William James\} and Dorothy Codoni and Neerav Darji",

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AU - Qi, Sheng

AU - Belton, Peter

AU - McAuley, William James

AU - Codoni, Dorothy

AU - Darji, Neerav

PY - 2013/4

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N2 - Gelucire 50/13, a polyoxyethylene glycol glyceride mixture, has been widely used in drug delivery, but its moisture uptake behaviour is still poorly understood. In this study, the effects of relative humidity, temperature, and drug incorporation on the moisture uptake of Gelucire are reported in relation to their practical implications for preparation of solid dispersions using this material

AB - Gelucire 50/13, a polyoxyethylene glycol glyceride mixture, has been widely used in drug delivery, but its moisture uptake behaviour is still poorly understood. In this study, the effects of relative humidity, temperature, and drug incorporation on the moisture uptake of Gelucire are reported in relation to their practical implications for preparation of solid dispersions using this material

U2 - 10.1007/s11095-012-0948-5

DO - 10.1007/s11095-012-0948-5

M3 - Article

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EP - 1136

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 4

ER -

Moisture uptake of polyoxyethylene glycol glycerides used as matrices for drug delivery: kinetic modelling and practical implications

Abstract

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