Abstract
The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the point centred atom charge approach in an attempt to find some common features of structurally unrelated inhibitors. A series of inhibitors of bacterial MDR were studied and there is a high similarity between these in terms of their shape, presence and orientation of aromatic ring moieties. A comparison of the lipophilic properties of these molecules has also been conducted suggesting that this factor is important in MDR inhibition.
Original language | English |
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Pages (from-to) | 37-47 |
Number of pages | 11 |
Journal | International Journal of Molecular Sciences (IJMS) |
Volume | 5 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2004 |