Abstract
The first carbon monoxide-releasing molecules (CO-RMs) based on mu2-alkyne dicobalt(0)hexacarbonyl complexes are reported. The alkyne substituents significantly affect the rate of CO-release, cytotoxicity and cell viability. Mechanistic studies provide insight into the CO-RM activation pathways.
Original language | English |
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Pages (from-to) | 3653-6 |
Number of pages | 4 |
Journal | Dalton Transactions |
Issue number | 19 |
DOIs | |
Publication status | Published - 21 May 2009 |
Keywords
- Alkynes
- Animals
- Carbon Monoxide
- Cell Survival
- Cobalt
- Drug Carriers
- Organometallic Compounds
- Temperature
- Time Factors
- Journal Article