Mu2-alkyne dicobalt(0)hexacarbonyl complexes as carbon monoxide-releasing molecules (CO-RMs): probing the release mechanism

Anthony J Atkin, Sophie Williams, Philip Sawle, Roberto Motterlini, Jason M Lynam, Ian J S Fairlamb

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

The first carbon monoxide-releasing molecules (CO-RMs) based on mu2-alkyne dicobalt(0)hexacarbonyl complexes are reported. The alkyne substituents significantly affect the rate of CO-release, cytotoxicity and cell viability. Mechanistic studies provide insight into the CO-RM activation pathways.

Original languageEnglish
Pages (from-to)3653-6
Number of pages4
JournalDalton Transactions
Issue number19
DOIs
Publication statusPublished - 21 May 2009

Keywords

  • Alkynes
  • Animals
  • Carbon Monoxide
  • Cell Survival
  • Cobalt
  • Drug Carriers
  • Organometallic Compounds
  • Temperature
  • Time Factors
  • Journal Article

Fingerprint

Dive into the research topics of 'Mu2-alkyne dicobalt(0)hexacarbonyl complexes as carbon monoxide-releasing molecules (CO-RMs): probing the release mechanism'. Together they form a unique fingerprint.

Cite this