Abstract
Pharmaceutical scientists often wish to design dosage forms which
adhere to mucosal membranes to provide a localised effect. These
“mucoadhesive” formulations are typically evaluated using ex vivo animal
tissue, a large amount of which is sourced from laboratory animals slaughtered
for that tissue . The authors aim to produce a synthetic alternative to this
tissue, which frees scientists from the need to use laboratory animals and
provides a substrate which is inexpensive and homogenous. A substrate
containing 20 mol% N-acryloylglucosamine (AGA) and 80 mol% 2-
hydroxyethylmethacrylate (HEMA) was identified as being an effective mimic
for buccal mucosa when testing the mucoadhesion of tablets. This study
investigates the efficacy of this “mucosa-mimetic” material when testing for the
mucoadhesion of liquid and semi-solid dosage forms.
adhere to mucosal membranes to provide a localised effect. These
“mucoadhesive” formulations are typically evaluated using ex vivo animal
tissue, a large amount of which is sourced from laboratory animals slaughtered
for that tissue . The authors aim to produce a synthetic alternative to this
tissue, which frees scientists from the need to use laboratory animals and
provides a substrate which is inexpensive and homogenous. A substrate
containing 20 mol% N-acryloylglucosamine (AGA) and 80 mol% 2-
hydroxyethylmethacrylate (HEMA) was identified as being an effective mimic
for buccal mucosa when testing the mucoadhesion of tablets. This study
investigates the efficacy of this “mucosa-mimetic” material when testing for the
mucoadhesion of liquid and semi-solid dosage forms.
| Original language | English |
|---|---|
| Publication status | Published - 2016 |
| Event | Doctor Hadwen Trust Animal Replacement Science Conference - Duration: 9 Dec 2016 → … |
Conference
| Conference | Doctor Hadwen Trust Animal Replacement Science Conference |
|---|---|
| Period | 9/12/16 → … |