Multiscale Tomography: Probing The Nano-, Micro-, And Meso-Scale Resolution Of Inhalation Powder Structure

Parmesh Gajjar, Ioanna Danai Styliari, Timothy Burnett, Xizhong Chen, James A. Elliot, William J. Ganley, Robbert Hammond, Hien Nguyen, Robert Price, Kevin Roberts, Philip Withers, Darragh Murnane

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Understanding the agglomeration behavior of inhaled formulations is essential to ensure consistent aerosolization performance that maximizes drug deposition in the lower respiratory tract. Although many techniques are currently used to characterize critical material attributes (CMAs) such as the particle size distribution (PSD), these techniques suffer from low resolution, image in 2D projections, or are based on shape assumptions. Bearing in mind the importance of the powder microstructure, this work introduces the use of x-ray computed tomography (XCT) as a non- destructive, multiscale technique for characterizing inhalation formulations. Different grades of inhalation and tableting grade lactose have been analyzed using XCT, with distributions for size (volume weighted) and sphericity extracted and compared with laser diffraction and optical microscopy. The three-dimensional information provided from XCT provides a more accurate assessment of powder size and shape, demonstrating the promise for XCT as a valuable powder characterization technique that provides information about the powder microstructure, a descriptor now required from the U.S. Food and Drug Administration (Q3 equivalence).
Original languageEnglish
Title of host publicationRDD Europe 2019
PublisherRespiratory Drug Delivery, RDD
Number of pages14
Publication statusPublished - 7 May 2019
EventRespiratory Drug Delivery Europe 2019 - Estoril Congress Center, Lisbon, Portugal
Duration: 7 May 201910 May 2019


ConferenceRespiratory Drug Delivery Europe 2019
Abbreviated titleRDD Europe 2019
Internet address


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