Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons

Zhaowei Liu, Tao Zhang, Guogang Ren, Zhuo Yang

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)
188 Downloads (Pure)

Abstract

The aim of this study was to investigate the actions of silver nanoparticles (nano-Ag) on glutamatergic synaptic transmission and excitability in hippocampal CA1 pyramidal neurons with whole cell patch technique. The amplitude of miniature excitatory postsynaptic currents (mEPSCs) was inhibited by silver nano-particles (nano-Ag) (10(-5) g/ml and 10(-4) g/ml), but the amplitude and frequency of spontaneous excitatory postsynaptic currents (sEPSCs) were increased by nano-Ag treatment (10(-5) g/ml and 10(-4) g/ml). Furthermore, nano-Ag (10(-5) g/ml and 10(-4) g/ml) increased the spontaneous network activity. These results provide further insights into the underlying mechanisms responsible for the effects of nano-Ag on central nervous system (CNS).

Original languageEnglish
Pages (from-to)414-423
Number of pages10
JournalNanotoxicology
Volume6
Issue number4
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Dive into the research topics of 'Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons'. Together they form a unique fingerprint.

Cite this