Nano-CuO inhibited voltage-gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G-proteins pathway

Z. Liu, S. Liu, Guogang Ren, T. Zhang, Z. Yang

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

The aim of this study was to investigate the effects of nano-CuO on voltage-gated sodium current (INa) in hippocampal CA1 neurons. The results suggested that nano-CuO inhibited amplitudes of INa currents and prolonged peak rise time of action potential (AP). The responses to nano-CuO were inhibited by reactive oxygen species (ROS) scavenger. However, the G-proteins inhibitor did not block the effects of nano-CuO. The effects of nano-CuO were mediated through activation of ROS-INa-AP signaling cascades and independent from G-proteins pathway.
Original languageEnglish
Pages (from-to)439-445
JournalJournal of Applied Toxicology
Volume31
Issue number5
DOIs
Publication statusPublished - 2011

Keywords

  • hippocampus
  • nano-CuO
  • reactive oxygen species
  • voltage-gated sodium current

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