TY - JOUR
T1 - Neuroprotective action of proline-rich polypeptide-1 in β-amyloid induced neurodegeneration in rats
AU - Yenkoyan, K.
AU - Aghajanov, M.
AU - Safaryan, K.
AU - Chavushyan, V.
AU - Sarkissian, J.
AU - Meliksetyan, I.
AU - Navasardyan, G.
AU - Galoyan, A.
N1 - Original article can be found at: http://www.sciencedirect.com/ Copyright Elsevier [Full text of this article is not available in the UHRA]
PY - 2011/8
Y1 - 2011/8
N2 - It is recognized that the main trigger of Alzheimer disease related neurodegeneration is β-amyloid peptide, which subsequently generates different metabolic disorders in neuron and finally leads to neuronal death. Several biologically active products were tested as neuroprotectors, but only few of them demonstrated any efficiency.Proline-rich polypeptide-1 was tested as a neuroprotective agent on Aβ25-35 animal model of Alzheimer disease. Biochemical analysis (determination of spectrum of neuroactive amino acids, such as glutamate, gamma-aminobutyric acid, glycine, aspartate and taurine), as well as behavioral, electrophysiological and morphological studies were performed to reveal the neuroprotective potential of proline-rich polypeptide in rats.Based on the results of our study it can be concluded that proline-rich polypeptide-1 has a potential to be one of the effective preventive or therapeutic agents against neurodegenerative disorders, such as Alzheimer disease.
AB - It is recognized that the main trigger of Alzheimer disease related neurodegeneration is β-amyloid peptide, which subsequently generates different metabolic disorders in neuron and finally leads to neuronal death. Several biologically active products were tested as neuroprotectors, but only few of them demonstrated any efficiency.Proline-rich polypeptide-1 was tested as a neuroprotective agent on Aβ25-35 animal model of Alzheimer disease. Biochemical analysis (determination of spectrum of neuroactive amino acids, such as glutamate, gamma-aminobutyric acid, glycine, aspartate and taurine), as well as behavioral, electrophysiological and morphological studies were performed to reveal the neuroprotective potential of proline-rich polypeptide in rats.Based on the results of our study it can be concluded that proline-rich polypeptide-1 has a potential to be one of the effective preventive or therapeutic agents against neurodegenerative disorders, such as Alzheimer disease.
KW - β-Amyloid
KW - neurodegeneration
KW - neuroprotection
KW - PRP-1
UR - http://www.scopus.com/inward/record.url?scp=80053259049&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2011.08.003
DO - 10.1016/j.brainresbull.2011.08.003
M3 - Article
AN - SCOPUS:80053259049
SN - 0361-9230
VL - 86
SP - 262
EP - 271
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 3-4
ER -