New psychoactive substances (NPS), psychedelic experiences, and dissociation: clinical and clinical pharmacological issues

Fabrizio Schifano, Flavia Napoletano, Stephania Chiappini, Laura Orsolini, Amira Guirguis, John Martin Corkery, Stefania Bonaccorso, Angelo Ricciardi, Norbert Scherbaum, alessandro vento

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
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Abstract

Purpose of the review: A significant increase in the number, type, and availability of new psychoactive substances (NPS) with dissociative and psychedelic potential has occurred worldwide over the last few decades. Psychedelic substances have historically been used in order to achieve altered states of consciousness such as dissociative states. We aimed here at describing both the large number of novel ketamine-like dissociatives and tryptamine/lysergamide/phenethylamine psychedelics available, whilst describing the acute/long term clinical scenarios most commonly associated with their intake.
Recent findings: An updated overview of the clinical and clinical pharmacological issues related to some of the most popular NPS categories has been provided, describing both psychosis and remaining psychopathological issues related to them.
Conclusions: Although the complex link between NPS and psychiatric illnesses is yet to be fully understood, NPS misuse is now a significant clinical issue and an increasing challenge for clinicians working in both mental health and emergency departments.
Original languageEnglish
Pages (from-to)140-152
JournalCurrent Addiction Reports
Volume6
Issue number2
Early online date23 Apr 2019
DOIs
Publication statusE-pub ahead of print - 23 Apr 2019

Keywords

  • New psychoactive substances
  • NPS
  • dissociation
  • Psychedelics
  • drug-induced psychosis
  • drug misuse

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