NK1 antagonists based on seven membered lactam scaffolds

J. M. Elliott, E. J. Carlson, G. G. Chcchi, O. Dirat, M. Dominguez, U. Gerhard, R. Jelley, A. B. Jones, M. M. Kurtz, K. I. Tsao, A. Wheeldon

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


A new class of high affinity hNK(1)R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties. (c) 2006 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)2929-2932
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number11
Publication statusPublished - 1 Jun 2006


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