NK1 antagonists based on seven membered lactam scaffolds

J. M.  Elliott; E. J.  Carlson; G. G.  Chcchi; O. Dirat; M. Dominguez; U. Gerhard; R. Jelley; A. B. Jones; M. M.  Kurtz; K. I.  Tsao; A.  Wheeldon

doi:10.1016/j.bmcl.2006.02.080

NK1 antagonists based on seven membered lactam scaffolds

J. M. Elliott
, E. J. Carlson
, G. G. Chcchi
, O. Dirat
, M. Dominguez
, U. Gerhard
, R. Jelley
, A. B. Jones
, M. M. Kurtz
, K. I. Tsao
, A. Wheeldon

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A new class of high affinity hNK(1)R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties. (c) 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2929-2932
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2006.02.080
Publication status	Published - 1 Jun 2006

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10.1016/j.bmcl.2006.02.080

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title = "NK1 antagonists based on seven membered lactam scaffolds",

abstract = "A new class of high affinity hNK(1)R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties. (c) 2006 Elsevier Ltd. All rights reserved.",

author = "Elliott, \{J. M.\} and Carlson, \{E. J.\} and Chcchi, \{G. G.\} and O. Dirat and M. Dominguez and U. Gerhard and R. Jelley and Jones, \{A. B.\} and Kurtz, \{M. M.\} and Tsao, \{K. I.\} and A. Wheeldon",

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T1 - NK1 antagonists based on seven membered lactam scaffolds

AU - Elliott, J. M.

AU - Carlson, E. J.

AU - Chcchi, G. G.

AU - Dirat, O.

AU - Dominguez, M.

AU - Gerhard, U.

AU - Jelley, R.

AU - Jones, A. B.

AU - Kurtz, M. M.

AU - Tsao, K. I.

AU - Wheeldon, A.

PY - 2006/6/1

Y1 - 2006/6/1

N2 - A new class of high affinity hNK(1)R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties. (c) 2006 Elsevier Ltd. All rights reserved.

AB - A new class of high affinity hNK(1)R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties. (c) 2006 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.bmcl.2006.02.080

DO - 10.1016/j.bmcl.2006.02.080

M3 - Article

SN - 0960-894X

VL - 16

SP - 2929

EP - 2932

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

NK1 antagonists based on seven membered lactam scaffolds

Abstract

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