TY - JOUR
T1 - Not so EEZE
T2 - the ‘EDHF’ antagonist 14, 15 Epoxyeicosa-5(z)-enoic Acid has vasodilator properties in mesenteric arteries
AU - MacKenzie, Louise Susan
AU - Falck, John R.
AU - Mitchell, Jane A.
PY - 2004/12/15
Y1 - 2004/12/15
N2 - P-450 metabolites, including the epoxyeicosatrienoic acids, are likely candidates for endothelial derived hyperpolarising factor (EDHF). In the present study, we confirm that the stable analogue 11-nonyloxyundec-8(Z)-enoic acid is a vasodilator of murine vessels. However, we also show that the ‘epoxyeicosatrienoic acid receptor’ antagonist 14,15 EEZE similarly dilates murine vessels contracted with U46619, prostaglandin F2α or methoxamine, but not with endothelin-1 or potassium. We suggest that 14,15 EEZE is a partial agonist for the epoxyeicosatrienoic acids/EDHF receptor. These results illustrate an important pharmacological property of this antagonists, which is being increasingly used to study the nature of EDHF
AB - P-450 metabolites, including the epoxyeicosatrienoic acids, are likely candidates for endothelial derived hyperpolarising factor (EDHF). In the present study, we confirm that the stable analogue 11-nonyloxyundec-8(Z)-enoic acid is a vasodilator of murine vessels. However, we also show that the ‘epoxyeicosatrienoic acid receptor’ antagonist 14,15 EEZE similarly dilates murine vessels contracted with U46619, prostaglandin F2α or methoxamine, but not with endothelin-1 or potassium. We suggest that 14,15 EEZE is a partial agonist for the epoxyeicosatrienoic acids/EDHF receptor. These results illustrate an important pharmacological property of this antagonists, which is being increasingly used to study the nature of EDHF
U2 - 10.1016/j.ejphar.2004.09.062
DO - 10.1016/j.ejphar.2004.09.062
M3 - Article
SN - 0014-2999
VL - 506
SP - 165
EP - 168
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -