Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing

Michael T. Cook; Sarah L. Smith; Vitaliy V. Khutoryanskiy

doi:10.1039/c5cc02428e

Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing

Michael T. Cook, Sarah L. Smith, Vitaliy V. Khutoryanskiy

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

202 Downloads (Pure)

Abstract

Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ex vivo gastric mucosa, when using a dynamic method of assessing mucoadhesion

Original language	English
Pages (from-to)	14447-14450
Journal	Chemical Communications
Volume	51
Early online date	21 Jul 2015
DOIs	https://doi.org/10.1039/c5cc02428e
Publication status	E-pub ahead of print - 21 Jul 2015

Access to Document

10.1039/c5cc02428eLicence: CC BY

Published VersionFinal published version, 1.45 MBLicence: CC BY

Cite this

@article{db7b0fe79a4641d3a0d71c83a8291782,

title = "Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing",

abstract = "Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ex vivo gastric mucosa, when using a dynamic method of assessing mucoadhesion",

author = "Cook, {Michael T.} and Smith, {Sarah L.} and Khutoryanskiy, {Vitaliy V.}",

note = "This is an Open Access article is licensed under a Creative Commons Attribution 3.0 Unported Licence. ",

year = "2015",

month = jul,

day = "21",

doi = "10.1039/c5cc02428e",

language = "English",

volume = "51",

pages = "14447--14450",

journal = "Chem. Commun.",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing

AU - Cook, Michael T.

AU - Smith, Sarah L.

AU - Khutoryanskiy, Vitaliy V.

N1 - This is an Open Access article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

PY - 2015/7/21

Y1 - 2015/7/21

N2 - Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ex vivo gastric mucosa, when using a dynamic method of assessing mucoadhesion

AB - Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ex vivo gastric mucosa, when using a dynamic method of assessing mucoadhesion

U2 - 10.1039/c5cc02428e

DO - 10.1039/c5cc02428e

M3 - Article

VL - 51

SP - 14447

EP - 14450

JO - Chem. Commun.

JF - Chem. Commun.

SN - 1359-7345

ER -

Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing

Abstract

Access to Document

Fingerprint

Cite this